Key takeaways
Fluorouracil (Efudex) and diclofenac (Solaraze) are both topical medications used to treat actinic keratosis, but they have some key differences. Fluorouracil is an antimetabolite that works by interfering with the DNA of abnormal skin cells, preventing them from growing. It is available in 2% and 5% strengths and can also treat basal cell carcinoma, a type of skin cancer, with the 5% formulation. Diclofenac, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) that blocks proteins involved in cell and blood vessel formation, specifically targeting actinic keratosis. While fluorouracil can cause significant skin reactions like burning and crusting, diclofenac tends to have fewer side effects but may take longer to show results. Additionally, diclofenac can make your skin more sensitive to the sun, increasing the risk of sunburns. Both medications require a prescription and should be used with caution, especially in pregnant women.
