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Cabenuva vs. Biktarvy

Cabenuva (cabotegravir / rilpivirine) is a long-acting combination medication used to treat human immunodeficiency virus (HIV) infection in certain adults and teens. It includes two injections — cabotegravir and rilpivirine — which are from different classes of antiviral medications. A healthcare professional gives both shots in the buttock muscle either once a month or every other month. It’s meant for people whose HIV is already well controlled and who haven’t had treatment failure. The most common side effects are injection-site reactions, such as pain, redness, and hardening of the skin where the shot is given.

• HIV treatment

• Injection-site reactions (75-83%)
• Fever (8%)
• Feeling tired (5%)
• Headache (4%)
• Muscle or bone pain (3%)
• Nausea (3%)
• Trouble sleeping (2%)
• Dizziness (2%)
• Rash (2%)

• Serious allergic reaction
• Side effects after the injection
• Liver problems
• Depression and mood changes
• Interaction with other medications
• Long-acting effects of the injection

Biktarvy is a combination antiretroviral medication. It contains bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF). Biktarvy is a complete treatment for human immunodeficiency virus (HIV) infection. It's approved for adults and children who weigh at least 30 pounds with HIV. Biktarvy is a first-choice option for people starting HIV treatment. This medication comes as a single tablet and is taken by mouth once daily. It can cause side effects, such as nausea, diarrhea, and headache.

• Treatment of HIV in people weighing at least 30 lbs:
  • Who are starting treatment for the first time
  • Who've tried other HIV treatments that haven't worked well enough and who don't have resistance to certain HIV medications
  • Who want to switch HIV treatment and have a viral load of less than 50 copies/mL

• Higher creatine kinase levels (8%)
• Diarrhea (6%)
• Nausea (6%)
• Headache (5%)

• Worsening of hepatitis B infection in people with HIV and hepatitis B
• Overactive immune system
• Kidney problems
• Liver problems and lactic acidosis
• Interaction with other medications