Compare Arcalyst vs. Kineret
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Arcalyst (rilonacept)Kineret (anakinra)
- Arcalyst (rilonacept)Kineret (anakinra)
Summary of Arcalyst vs. Kineret
Summary for Interleukin-1 blockerPrescription onlyArcalyst (rilonacept) is a prescription medication that's used to treat adults and children with certain rare inflammatory conditions, including cryopyrin-associated periodic syndromes (CAPS), deficiency of interleukin-1 receptor antagonist (DIRA), and recurrent pericarditis (RP). It's given as an injection under the skin once a week. The medication is approved for use in adults and children 12 years and older. Common side effects include injection site reactions and upper respiratory tract infections.
Summary for Biologic DMARDPrescription onlyKineret (anakinra) is an injectable medication used to treat rheumatoid arthritis (RA) when certain other medications haven't worked well. Kineret (anakinra) is unique in that it's the only FDA-approved RA medication that blocks a specific protein called interleukin-1 (IL-1) that's responsible for swelling and pain. Kineret (anakinra) can also be used to treat certain other auto-inflammatory conditions. It's injected under the skin, typically once daily. <br> In November of 2022, Kineret (anakinra) received Emergency Use Authorization (EUA) from the FDA to improve survival and shorten hospital stay for certain people hospitalized with coronavirus disease 19 (COVID-19).
Indications of Arcalyst vs. Kineret
Indications for•Treatment of cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome (FCAS) and Muckle-wells Syndrome (MWS)•Maintenance of deficiency of interleukin-1 receptor antagonist (DIRA)•Treatment and prevention of recurrent pericarditis (RP)Pros and Cons of Arcalyst vs. Kineret
Pros and Const for Interleukin-1 blockerPros•Only injected once a week•Can be used to treat adults and children•The first and only FDA-approved medication for RPCons•Commonly causes injection-site reactions•Carries a risk of serious infections•Must prepare the medication before usingPros and Const for Biologic DMARDPros•Available as a prefilled syringe for easier administration•Injection can be given at home after proper training (but not for COVID-19)•Typically given once dailyCons•Needs to be injected, not good for people who don't like needles•Can weaken the immune system and raise the risk for infections•Can take a month or more to see noticeable improvements in symptoms for RACommon Side Effects of Arcalyst vs. Kineret
Common Side Effects for•Pain, itching, and swelling around the injection site (48%)•Upper respiratory tract infection (26%)Side effects listed above are for people with CAPS. Similar side effects were reported in people with DIRA and RP.
Common Side Effects forRA:
•Injection-site reactions (71%)•Sore throat, runny nose, and other symptoms of an infection (up to 39%)•Headache (12%)•Nausea (8%)•Diarrhea (7%)NOMID:
•Injection-site reactions (16%)•Headache (14%)•Vomiting (14%)•Joint stiffness (12%)•Fever (12%)•Runny nose and sore throat (12%)Please note: The safety profile of Kineret (anakinra) in people treated for DIRA is similar to that of for NOMID.
Warnings of Arcalyst vs. Kineret
Common Side Effects for•Serious infections•Possible risk of cancer•Higher cholesterol and triglycerides levels•Interaction with vaccinesCommon Side Effects for•Risk of serious infections•Severe allergic reactions•VaccinesPrices with our coupons for Arcalyst vs. Kineret
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