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Alrex Coupon - Alrex 5ml of 0.2% eye dropper

Alrex

loteprednol
Used for Allergic Conjunctivitis
Used for Allergic Conjunctivitis

Alrex (loteprednol) is a prescription corticosteroid eye drop used short-term to treat adults with seasonal eye allergies, or allergic conjunctivitis. It works by reducing redness, itching, and swelling in the eyes. You typically apply it directly to the affected eye four times a day for 2 weeks. Common side effects include blurry vision, dry eyes, and a burning feeling right after using the drops.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Daisy Chau, PharmD
Last reviewed on July 28, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
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What is Alrex (loteprednol)?

What is Alrex (loteprednol) used for?

How Alrex (loteprednol) works

Alrex (loteprednol) is a corticosteroid. While the exact way it works in the eye isn't fully known, the medication is thought to block certain chemicals that cause inflammation. This helps lower inflammation in the eye to relieve symptoms like swelling, itchiness, and redness.

Are you looking for information on loteprednol (Lotemax) instead?
When does Alrex (loteprednol) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsAlrex
Drug ClassCorticosteroid
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$378.95(save 18.56%)
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$308.62
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What are the side effects of Alrex (loteprednol)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Blurry vision
  • Burning right after using the drop
  • Eye discharge
  • Dry eyes
  • Watery eyes
  • Feeling like something is in the eye
  • Itchy eyes
  • Sensitivity to light
Note: All common side effects listed above were reported in 5% to 15% of people in studies.

Other Side Effects

  • Pink eye
  • Cornea problems
  • Redness of the eyelid
  • Eye irritation, pain, or discomfort
  • Headache
  • Runny or stuffy nose
  • Sore throat

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision or other change in vision

redness or swelling of the eye

sensitivity of the eyes to light

swelling of the membrane covering the white part of the eye

Less common

Decreased vision

discharge from the eye

eye discomfort, irritation, or pain

redness of the eyelid or inner lining of the eyelid

tiny bumps on the inner lining of the eyelid

Incidence not known

Blindness

gradual blurring or loss of vision

loss of vision

nausea

slow wound healing

tearing

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning feeling when medicine is applied

dry eyes

feeling of something in the eye

headache

itching

runny nose

sore throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Alrex (loteprednol)

thumbs-up

Pros

Starts working within 2 hours

Specifically approved for seasonal eye allergies

Applied directly where the pain or inflammation is

thumbs-down

Cons

Needs to be used four times per day

Slows healing and raises your risk of eye infection

Might be difficult for some people to use correctly

pharmacist-tips

Pharmacist tips for Alrex (loteprednol)

pharmacist

  • Alrex (loteprednol) is an eye drop medication that you should place only on the surface of your eye. Don’t put it in your mouth, nose, ears, or on your skin.

    • Don’t let the tip of the Alrex (loteprednol) bottle touch your eye, fingers, or any surface. This can contaminate the drops and cause an infection. If your eye redness or itching gets worse, talk to your prescriber.

      • If you wear soft contact lenses, take them out before using Alrex (loteprednol). Wait at least 10 minutes after using Alrex (loteprednol) before putting your contacts back in. It’s best not to wear contact lenses at all if your eye is red.

        • Let your prescriber know if your eye symptoms don't start to get better after 2 days of using Alrex (loteprednol). They might consider a different medication to help relieve your symptoms.

          • Store Alrex (loteprednol) at room temperature. Keep the bottle in its box to protect it from light.

            How to use Alrex (loteprednol):

            • Shake the bottle well before each use because it's a suspension. This helps mix the medicine evenly.

              • Tilt your head back, look up, and gently pull your lower eyelid down to make a small pocket. Hold the bottle upside down right above your eye.

                • Squeeze out one drop into the pocket. Close your eye and gently press the inner corner for about a minute to keep the medication in your eye.

                  faqs

                  Frequently asked questions about Alrex (loteprednol)

                  Is Alrex (loteprednol) a steroid?
                  Yes, Alrex (loteprednol) is a steroid. It helps reduce eye inflammation to treat symptoms like itchy, red, or watery eyes caused by seasonal allergies.
                  How long does it take for Alrex (loteprednol) to work?
                  In studies, it took about 2 hours for Alrex (loteprednol) to start working to relieve redness and itching. If you don’t see any improvement after two days of using the medication, contact your prescriber. They might want to recheck your symptoms or adjust your treatment.
                  How long can I use Alrex (loteprednol)?
                  You can use Alrex (loteprednol) for as long as your symptoms last, but usually not more than two weeks without checking in with your prescriber. If you use it for more than 10 days, make sure to follow up with your prescriber. They’ll check for long-term side effects like high eye pressure or infection.
                  Is Alrex (loteprednol) over the counter?
                  No, you can't find Alrex (loteprednol) over the counter or along the aisles in the pharmacy. You'll need a prescription from a healthcare professional for this eye drop medication.
                  Can you use expired Alrex (loteprednol)?
                  No, don't use Alrex (loteprednol) if it's expired because it might not work as well. Expired eye drops can also lead to infections if they’ve been contaminated with germs. Check the expiration date on the bottle or box, and let your pharmacist or prescriber know if it’s expired.
                  What's the difference between Alrex and Lotemax?
                  Both Alrex and Lotemax contain the same steroid, loteprednol, as the active ingredient. But they come in different strengths: Alrex has 0.2% of loteprednol, while Lotemax has 0.5% of loteprednol. Since Lotemax is stronger, it's FDA-approved to treat more serious conditions, including inflammation after eye surgery. In addition, while both are available as eye drops, Lotemax also comes in a gel and an ointment form. If you’re not sure which one is right for you, talk to your prescriber to compare the two medications.
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                  What are the risks and warnings for Alrex (loteprednol)?

                  Alrex (loteprednol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Serious eye problems

                  • Risk factors: Using Alrex (loteprednol) for a long time | History of glaucoma

                    Using Alrex (loteprednol) for a long time can lead to serious eye problems like glaucoma or cataracts. This could lead to vision loss or blind spots. Your prescriber will likely monitor your eye pressure if you use the medication for more than 10 days. Tell your prescriber if you have any vision changes using these eye drops.

                    risk-warning

                    Eye infections

                    • Risk factors: Using Alrex (loteprednol) for a long time | History of eye infections | Certain eye conditions

                      Using Alrex (loteprednol) for a long time can make it harder for your body to fight eye infections. This can raise the chance of getting a new infection or making an existing one worse. Let your prescriber know if you have symptoms of an eye infection, like worsening redness, itching, swelling, or discharge.

                      Steroid eye drops like Alrex (loteprednol) can make viral infections, like herpes simplex, worse or last longer. Fungal infections in the eye can also happen with long-term steroid use. If you've had an eye infection in the past, let your prescriber know before using this eye drop.

                      risk-warning

                      Damage to contact lenses

                      Alrex (loteprednol) contains a preservative that absorbs into soft contact lenses and damages them. If your prescriber says it's okay to wear contacts during treatment, take them out before using the drops. Wait at least 10 minutes after using Alrex (loteprednol) before putting your contact lenses back in.

                      dosage

                      Alrex (loteprednol) dosage forms

                      The average cost for 1 eye dropper of 5ml of 0.2% of Alrex (loteprednol) is $308.62 with a free GoodRx coupon. This is 18.56% off the average retail price of $378.95.
                      eye dropper
                      Eye dropper
                      DosageQuantityPrice as low asPrice per unit
                      5ml of 0.2%1 eye dropper$308.62$308.62
                      10ml of 0.2%1 eye dropper$587.91$587.91

                      Typical dosing for Alrex (loteprednol)

                      The typical dose is 1 drop into the affected eye(s) four times per day.

                      interactions

                      Interactions between Alrex (loteprednol) and other drugs

                      Alrex (loteprednol) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Alrex (loteprednol). Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      • Bemiparin
                      • Lutetium Lu 177 Dotatate
                      • Macimorelin
                      • Nadroparin
                      • Sargramostim

                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      • Auranofin
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                      contraindications-icon

                      Alrex (loteprednol) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Alrex (loteprednol) will not be safe for you to take.

                      • Bacterial, viral, or fungal infection in the eye

                      alternatives

                      What are alternatives to Alrex (loteprednol)?

                      There are a number of medications that your doctor can prescribe in place of Alrex (loteprednol). Compare a few possible alternatives below.
                      Alrex (loteprednol)
                      Used for:
                      $308.62 Lowest GoodRx priceView Prices
                      Prednisolone (Pred Forte)
                      Used for:

                      • Eye injury

                      • Swelling or allergies in the eye

                      $17.70 Lowest GoodRx priceView Prices
                      Olopatadine (Pataday)
                      Used for:
                      $13.85 Lowest GoodRx priceView Prices
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                      Alrex (loteprednol) images

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                      References

                      Best studies we found

                      American Academy of Allergy, Asthma & Immunology. (2024). Tips for administering eye drops.

                      Bausch & Lomb Incorporated. (2022). Alrex- loteprednol etabonate suspension/ drops [package insert]. DailyMed.

                      Centers for Disease Control and Prevention. (2025). What causes HSV (herpes simplex virus) keratitis.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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