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Mozobil

Plerixafor

PLERIXAFOR helps your body increase the amount of white blood cells in the blood. It is used to increase white blood cells before a stem cell transplant. Compare immune response modifiers.
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What is Mozobil?

Commonly Used Brand Name(s)Mozobil

Therapeutic ClassificationsHematopoietic

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OverviewTOP

Plerixafor is used to treat non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). It is used together with granulocyte-colony stimulating factor or G-CSF (e.g., filgrastim, pegfilgrastim) to mobilize hematopoietic stem cells (HSC) for collection and transplantation.

This medicine is available only with your doctor's prescription.

Proper UseTOP

A nurse or other trained health professional may give you this medicine. This medicine is given as a shot under your skin.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies have not been performed on the relationship of age to the effects of plerixafor in the pediatric population.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of plerixafor in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving plerixafor.

PregnancyTOP

Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Yellow Fever Vaccine

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bone marrow cancer or other bone marrow problems (e.g., leukemia) or
  • Enlarged spleen or
  • Leukocytosis (high white blood cell count) or
  • Thrombocytopenia (low blood platelet count)—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

PrecautionsTOP

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away. Do not breastfeed while you are using this medicine.

Check with your doctor right away if you are having a pain in the upper left part of your abdomen or at the tip of the left shoulder. This could be a symptom of a serious side effect with the spleen.

Tell your doctor right away if you have slow heartbeat; severe, unusual tiredness or weakness; cold sweats; confusion; or dizziness, faintness, or lightheadedness when getting up from a lying or sitting position after you get the injection.

If you develop a skin rash, hives, swelling around the eyes, shortness of breath, or any allergic reaction to this medicine, stop taking the medicine and check with your doctor as soon as possible.

This medicine may cause diarrhea, nausea, vomiting, or stomach pain in some patients. Ask your doctor or nurse about other ways to control these side effects.

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