Key takeaways
Etonogestrel / ethinyl estradiol (NuvaRing) and medroxyprogesterone (Depo-Provera) are both medications used to prevent pregnancy. However, they belong to different medication classes and have distinct characteristics. NuvaRing is a combined hormonal contraceptive containing both estrogen and progestin, while Depo-Provera is a progestin-only contraceptive. NuvaRing is a flexible plastic ring inserted into the vagina for three weeks, followed by a one-week break, whereas Depo-Provera is an injection given every three months by a healthcare professional. Depo-Provera may be slightly more effective than Nuvaring (about 94% versus about 91% with typical use). Both medications come in brand-name and lower-cost generic forms. Common side effects of NuvaRing include headaches and vaginal irritation, while Depo-Provera may cause weight gain and changes in menstrual bleeding. Additionally, long-term use of Depo-Provera can weaken bones, so it is typically not recommended for use longer than two years. Both medications do not protect against sexually transmitted infections, so using condoms is advised to protect against sexually transmitted infections.
