Phenazopyridine (Pyridium) is a pain medication used to relieve urinary urgency, pain, and discomfort caused by a urinary tract infection (UTI), surgery, or catheters. The medication is available over the counter (OTC) at lower strengths, and by prescription at higher strengths. You shouldn't take it for more than 2 days to treat symptoms of a UTI without speaking to your healthcare provider since it can hide a worsening infection.
Relief of urinary pain, burning, urgency, and frequency caused by infection, trauma, catheter use, or surgery
It's not exactly known how phenazopyridine (Pyridium) works. But it's thought to work directly on the lining of the urinary tract to relieve pain.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Available over-the-counter and by prescription
Works quickly to relieve urinary pain and discomfort
Has very few interactions with other medications
Available as a lower-cost generic
Might need to take it three times a day
Only treats the symptoms of a UTI, not the underlying cause
Can cause stains to clothing, fabric, linen, and even soft contact lenses
Not the safest option for people with serious kidney problems
Take phenazopyridine (Pyridium) with or after meals (or a snack). Taking it with food can lessen stomach upset. And make sure you drink a full glass (8 oz) of water when taking your dose.
It's normal for your urine to change into a red-orange color when taking phenazopyridine (Pyridium). Although it isn't harmful, this can stain your clothes, particularly your undergarments. Take special care to avoid this staining like wearing a pantyliner.
Phenazopyridine (Pyridium) can also stain soft contact lenses if you touch them after handling the tablets. If possible, avoid wearing contacts until you are done taking this medication to prevent this problem.
If you're using phenazopyridine (Pyridium) along with an antibiotic for a UTI, don't take this medication for more than 2 days unless your healthcare provider specifically told you to do so.
Don't take phenazopyridine (Pyridium) more than the recommended dose. Many of the serious side effects of this medication happen when too much of it is taken. If you feel this medication isn't working well enough, contact your provider because you might need to be examined for a more serious condition.
Since phenazopyridine (Pyridium) is a colored dye, it can cause false results in people undergoing a urinalysis (a type of urine test). Make sure to tell your provider that you're taking phenazopyridine (Pyridium) if you're scheduled for a urine test.
Phenazopyridine (Pyridium) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: G6PD deficiency
In people with a blood condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency, phenazopyridine (Pyridium) can raise the risk of developing hemolytic anemia. This condition causes red blood cells to break down faster than they can be made, so the overall red blood cell count will be low. Contact your provider if you experience paleness, feeling very tired, fast heart rate, or shortness of breath.
Risk factors: People age 65 or older | Kidney problems
Some people have had serious side effects like kidney or liver damage while taking phenazopyridine (Pyridium). This is especially true when people take more than the recommended amount of the medication. Too much phenazopyridine (Pyridium) can cause hemolytic anemia even in people who don't have G6PD deficiency (see above). And your skin and the whites of your eyes can turn yellow if you take more medication than you should. Stop taking phenazopyridine (Pyridium) and talk to a healthcare provider right away if you start having fatigue, confusion, dizziness, yellowing of the skin and eyes, or a change in heartbeat.
Phenazopyridine (Pyridium) is available both OTC and by prescription. The OTC strengths are 95 mg, 97.5 mg, and 99.5 mg. The prescription strengths available are 100 mg and 200 mg.
OTC (adults and children 12 years old and older): The typical dose is 2 tablets by mouth three times a day after meals, as needed for up to 2 days.
Prescription (adults): The typical dose is 200 mg by mouth three times a day after meals. If you are using this along with an antibiotic for a UTI, you should only take this for a maximum of 2 days.
GoodRx has partnered with PatientsLikeMe to provide reviews on the different aspects of Phenazopyridine (Pyridium).
Learn more about the effectiveness of Phenazopyridine (Pyridium) based on real life experiences.
Based on 18 people taking this medication
3.9
4.0
3.8
Severity of side effects
Based on 23 people taking this medication
0%
50%
100%
Orange colored urine
22%
Amber colored urine
5%
Dizziness and feeling faint
5%
Headaches
5%
Nausea if taken on empty stomach
5%
Reasons people stopped taking Phenazopyridine (Pyridium)
Based on 33 people who have taken this medication
Course of treatment ended
61%
Other
22%
Did not seem to work
7%
Doctor's advice
7%
Personal research
4%
Side effects too severe
4%
How long people take Phenazopyridine (Pyridium)
Based on 39 people taking this medication
0%
50%
100%
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
People with severe kidney or liver problems
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AZO Urinary Pain Relief. (n.d.). Recommend AZO Urinary Pain Relief.
Drugs and Lactation Database (LactMed). (2018). Phenazopyridine. National Institute of Child Health and Human Development.
Eastham, J. H., et al. (2023). Phenazopyridine. StatPearls.
MedlinePlus. (2022). Glucose-6-phosphate dehydrogenase deficiency.
Method Pharmaceuticals. (2022). Phenazopyridine HCL 100mg [package insert]. DailyMed.
National Heart, Lung, and Blood Institute. (2022). Hemolytic anemia.
Richardson, S. R., et al. (2022). Glucose 6 phosphate dehydrogenase deficiency. StatPearls.
ScienceDirect. (2016). Azo dye. TrAC Trends in Analytical Chemistry.
Singh, M., et al. (2014). Phenazopyridine associated acute interstitial nephritis and review of literature. Renal Failure.
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