Krazati vs. Lumakras for Lung Cancer: Important Differences and Potential Risks.

Krazati

(adagrasib)

Lumakras

(sotorasib)

Summary for Krazati

Prescription only

Krazati (adagrasib) is a KRAS inhibitor that's FDA approved to treat advanced and metastatic non-small cell lung cancer (NSCLC) and colorectal cancer in adults with the KRAS G12C mutation. It’s typically used when previous treatments stop working. This medication is used alone to treat NSCLC. But for colorectal cancer, it's used with Erbitux (cetuximab), an infusion given once a week or every other week. Krazati (adagrasib) is conveniently available as an oral tablet which is taken by mouth twice a day. But it can commonly cause bothersome side effects such as diarrhea, nausea, and fatigue.

Indications for Krazati

Locally advanced or metastatic non-small cell lung cancer (NSCLC) with a KRAS G12C mutation, after having tried at least one previous cancer treatment
Locally advanced or metastatic colorectal cancer with a KRAS G12C mutation, together with Erbitux (cetuximab), after having tried certain previous cancer treatments

Pros and Cons for Krazati

Pros

Oral tablet that’s taken by mouth
Can be taken with or without food
Targeted therapy option for people with NSCLC or colorectal cancer with a KRAS G12C mutation

Cons

Has to be taken twice a day
Commonly causes diarrhea, nausea, vomiting, and fatigue
Only recommended after other treatments haven’t worked

Common Side Effects for Krazati

Diarrhea (70%)
Nausea (69%)
Lower blood cell counts (up to 64%)
Fatigue (59%)
Vomiting (56%)
Signs of stress to the liver or kidney on blood tests (up to 52%)
Muscle or bone pain (41%)
Liver injury (37%)
Kidney injury (36%)
Shortness of breath (35%)
Swelling (32%)
Loss of appetite (30%)

Note: Side effects noted above were reported in studies where Krazati (adagrasib) was used alone for lung cancer.

Warnings for Krazati

Severe digestive system problems
Life-threatening abnormal heart rhythm
Liver injury
Lung damage

Summary for Lumakras

Prescription only

Lumakras (sotorasib) is a medication that’s used for metastatic non-small cell lung cancer (NSCLC). In particular, it’s used for adults who have a specific mutation called KRAS G12C in their lung cancer. Lumakras (sotorasib) is typically recommended only when first-choice treatment doesn’t work anymore. It can be a convenient option since it’s taken by mouth once a day. But, it commonly causes bothersome side effects, like stomach upset and fatigue.

Indications for Lumakras

Metastatic non-small cell lung cancer (NSCLC) with a KRAS G12C mutation, after having tried at least one previous cancer treatment

Pros and Cons for Lumakras

Pros

Oral medication that’s taken once a day
Targeted therapy option for people with metastatic non-small cell lung cancer with a KRAS G12C mutation

Cons

Commonly causes diarrhea, nausea, muscle pain, and fatigue
Only recommended after first-choice treatment hasn’t worked

Common Side Effects for Lumakras

Diarrhea (42%)
Muscle or bone pain (35%)
Fatigue (26%)
Nausea (26%)
Cough (20%)

Warnings for Lumakras

Liver injury
Lung damage

Prices with our coupons for Krazati vs. Lumakras

Krazati180 tablets / 200mg

$22,128.54$23,393.95

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Lumakras120 tablets / 240mg of

$21,929.77-

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Krazati vs. Lumakras

Krazati

Lumakras

Summary for Krazati

Indications for Krazati

Pros and Cons for Krazati

Pros

Cons

Common Side Effects for Krazati

Warnings for Krazati

Summary for Lumakras

Indications for Lumakras

Pros and Cons for Lumakras

Pros

Cons

Common Side Effects for Lumakras

Warnings for Lumakras

Prices with our coupons for Krazati vs. Lumakras

Browse medications by letter

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Krazati

Lumakras

Summary for Krazati

Indications for Krazati

Pros and Cons for Krazati

Pros

Cons

Common Side Effects for Krazati

Warnings for Krazati

Summary for Lumakras

Indications for Lumakras

Pros and Cons for Lumakras

Pros

Cons

Common Side Effects for Lumakras

Warnings for Lumakras