Compare Asparlas vs. Oncaspar
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Asparlas (calaspargase pegol)Oncaspar (pegaspargase)
- Asparlas (calaspargase pegol)Oncaspar (pegaspargase)
Summary of Asparlas vs. Oncaspar
Summary for Asparagine specific enzymePrescription onlyAsparlas (calaspargase pegol) is a chemotherapy medication used to treat children and young adults aged 1 month to 21 years with acute lymphoblastic leukemia (ALL). It’s typically given together with other chemotherapy medications. Compared to other asparaginase treatments, Asparlas (calaspargase pegol) stays in the body the longest. The medication is given as an injection into the vein (intravenous, IV), usually no more than every 3 weeks. Some side effects include pancreatitis, serious liver problems, and blood clots.
Summary for Asparagine specific enzymePrescription onlyOncaspar (pegaspargase) is a cancer medication used to treat children and adults with acute lymphoblastic leukemia (ALL). It’s typically given together with other chemotherapy medications. Oncaspar (pegaspargase) stays in the body longer, so it can be given less often compared to L-asparaginase, a similar but older medication that’s no longer available. It’s given either as an injection into the vein (intravenous, IV) or into the muscle (intramuscular, IM), usually no more than every 2 weeks. Some side effects include high blood sugar, pancreatitis, and serious allergic reactions.
Indications of Asparlas vs. Oncaspar
Indications for•Treatment of children and young adults aged 1 month to 21 years with acute lymphoblastic leukemia (ALL) given together with other chemotherapy medicationsIndications for•Treatment of children and adults with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy regimen•As first-choice treatment•In people who had an allergic reaction to a similar medication called L-asparaginasePros and Cons of Asparlas vs. Oncaspar
Pros and Const for Asparagine specific enzymePros•Recommended as part of combination therapy for ALL in children and young adults•Works well for treating ALL, with 95% of people in studies achieving complete remission•Typically only given once every 3 weeksCons•Given as an intravenous injection, so it requires a needle•Not FDA approved for adults older than 21 years with ALL•Might cause serious side effects such as pancreas or liver problemsPros and Const for Asparagine specific enzymePros•Recommended as part of a first-choice treatment regimen for ALL•Available as an intravenous infusion or a quick intramuscular injection•Can be given no more than every 2 weeksCons•Might cause serious side effects such as blood clots or pancreatitis•Requires several premedications to prevent allergic reactions•Not safe for people with severe liver problemsCommon Side Effects of Asparlas vs. Oncaspar
Common Side Effects for•High liver enzymes (52%)•High bilirubin (20%)•Pancreatitis (18%)•Abnormal clotting labs (14%)•Diarrhea (9%)•Allergic reaction (8%)•Blood clot (8%)Note: Side effects shown above are from a study where Asparlas (calaspargase pegol) was given with other medications, so these side effects might not be solely due to Asparlas (calaspargase pegol).
Common Side Effects for•High liver enzymes (66%)•Neutropenic fever (40%)•High triglycerides (30%)•Low albumin (28%)•High bilirubin (25%)•High blood sugar (24%)•Pancreatitis (24%)•Abnormal clotting labs (up to 21%)Note: Only serious side effects are shown above from a study where Oncaspar (pegaspargase) was given with other medications, so these side effects might not be solely due to Oncaspar (pegaspargase).
Warnings of Asparlas vs. Oncaspar
Common Side Effects for•Allergic reactions•Pancreatitis•Blood clots•Bleeding•Liver problemsCommon Side Effects for•Allergic reactions•Blood clots•Pancreatitis•High blood sugar•Bleeding•Liver problemsPrices with our coupons for Asparlas vs. Oncaspar
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