Retinoid antiseptic combinations are used to treat acne. These medications work by combining a retinoid, which helps to unclog pores and reduce inflammation, with an antiseptic that kills bacteria on the skin. These combinations are typically available in topical forms, such as gels or creams, making them easy to apply directly to the affected area. Examples include adapalene/benzoyl peroxide (Epiduo Forte, Epiduo) and tretinoin/benzoyl peroxide (Twyneo). You can use these treatments to help clear your skin and reduce breakouts.