Chemet (succimer) is a medication taken by mouth to treat lead poisoning in children. The total treatment course lasts for a little less than 3 weeks. This medication works well, but it can't be used to prevent lead poisoning. It's also not meant to be used in place of avoiding lead exposure, so it's important to talk with your local public health department to find and remove sources of lead poisoning. This medication is brand name only, so it can be expensive.
Treatment of lead poisoning in children 12 months of age or older with blood lead levels above 45 mcg/dL
Chemet (succimer) is a heavy metal chelating agent used for lead poisoning. Chemet (succimer) works by reacting and binding to the lead in your body to help force it out through your urine.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Succimer may cause your urine, sweat, and feces to have an unpleasant odor.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Can be taken with or without food
Dose is adjustable based on body weight and condition
Capsules can be opened and taken with soft food
Can't be used to prevent lead poisoning
Have to get blood tests regularly during treatment
Full treatment takes almost 3 weeks
Only available as a brand name medication, so it can be expensive
It's important to find and get rid of the source of lead exposure, even if your child is being treated with Chemet (succimer). This medication won't be very helpful if your child continues to be exposed to lead. Contact your local department of public health for help and information about removing sources of lead.
It's important that your child drinks enough fluids and stay hydrated while taking Chemet (succimer). This will help make sure that the lead gets flushed out through urine.
Chemet (succimer) can cause liver problems. Your provider will likely ask you to take your child for weekly labs to check their liver during treatment, so please plan for these appointments.
Let your provider know right away if your child develops a rash. While rash can be a side effect of Chemet (succimer), it can also be a sign of an infection. This medication can lower white blood cell counts, which makes it harder for your child to fight off an infection.
Chemet (succimer) can cause false results for certain blood and urine tests. Before any tests, talk with your child's provider to see if Chemet (succimer) can interfere with (change) the results.
Pregnant mothers should talk with their provider before starting Chemet (succimer). It's possible that this medication can cause harm to the baby.
Don't breastfeed while taking Chemet (succimer). While it's not known whether this medication can get into breastmilk, heavy metals can get into breastmilk. So don't breastfeed if your blood lead level is high because lead can get passed on to your infant and cause harm.
Store Chemet (succimer) at room temperature, which is between 15 and 25 degrees Celcius (59 to 77 degrees Fahrenheit).
Chemet (succimer) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Chemet (succimer) might lower the levels of white blood cells, which are responsible for immune system function. Your provider will have your child get a blood test before starting Chemet (succimer) and weekly during their treatment. If the levels are too low, your provider might have your child stop the medication temporarily, or switch to a different treatment. Let the provider know right away if there are any signs of infections, such as fever, chills, confusion, pain, or swelling.
The blood lead levels and symptoms of lead poisoning might return after stopping Chemet (succimer). This is due to the low levels of lead after treatment, so the lead from the bones gets transferred out to the blood to balance out the levels. Your provider might have your child get a blood test once a week after treatment until levels are stable.
Dosing for Chemet (succimer) will depend on your child's weight or body surface area.
The typical starting dose is 10 mg/kg or 350 mg/m2 by mouth 3 times a day for 5 days. Then, your child will take 10 mg/kg or 350 mg/m2 by mouth 2 times a day for 14 days.
Your provider will continue to check your child's blood lead levels after the treatment is over to see if another course of treatment is needed.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
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