Generic Zometa

ZOLEDRONIC ACID lowers the amount of calcium loss from bone. It is used to treat too much calcium in your blood from cancer. It is also used to prevent complications of cancer that has spread to the bone. Compare bisphosphonates.

Zoledronic Acid Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checkups. It may be some time before you see the benefit from this medicine. Do not stop taking your medicine unless your doctor tells you to. Your doctor may order blood tests or other tests to see how you are doing.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

You should make sure that you get enough calcium and vitamin D while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Some people who take this medicine have severe bone, joint, and/or muscle pain. This medicine may also increase your risk for jaw problems or a broken thigh bone. Tell your doctor right away if you have severe pain in your jaw, bones, joints, or muscles. Tell your doctor if you have any pain that does not go away or that gets worse.

Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine. Take good care of your teeth while on this medicine. Make sure you see your dentist for regular follow-up appointments.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


black, tarry stools

blurred vision

chest pain







difficult or labored breathing


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


irregular heartbeat


lack or loss of strength


lower back or side pain

muscle pain or cramps

muscle trembling or twitching

nausea or vomiting

numbness and tingling around the mouth, fingertips, or feet

painful or difficult urination

pale skin

rapid weight gain


shaking of the hands, arms, feet, legs, or face

skin rash, cracks in the skin at the corners of the mouth, or soreness or redness around the fingernails and toenails

sore throat

sores, ulcers, or white spots on the lips or mouth


sudden sweating

swollen glands

tightness in the chest

trouble breathing with exercise

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Feeling of constant movement of self or surroundings

muscle cramps in the hands, arms, feet, legs, or face

muscle spasms

neck pain

pounding in the ears

rapid breathing

sensation of spinning

slow or fast heartbeat

sunken eyes

tingling of the hands or feet


Incidence not known

Blurred vision or other change in vision

decreased frequency or amount of urine

decreased vision

eye pain

eye tenderness

heavy jaw feeling

increased blood pressure

increased tearing

increased thirst

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loosening of a tooth

pain, swelling, or numbness in the mouth or jaw

redness of the eye

sensitivity of the eye to light

severe eye pain

swelling of the face, hands, fingers, lower legs, or ankles

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach pain

back pain

bad, unusual, or unpleasant (after) taste

bladder pain

blistering, crusting, irritation, itching, or reddening of the skin

bloody or cloudy urine

bone pain

burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings

change in taste


cracked lips

cracked, dry, or scaly skin


difficulty with swallowing


dry mouth

ear congestion

feeling sad or empty

frequent urge to urinate

hair loss or thinning hair



joint pain or swollen joints

loss of appetite

loss of interest or pleasure

loss of voice

muscle stiffness or difficulty with moving

nasal congestion or runny nose

pain, swelling, or redness in the joints

partial loss of feeling

seeing, hearing, or feeling things that are not there

sleepiness or unusual drowsiness

swelling or inflammation of the mouth


trouble concentrating

trouble sleeping

unusually cold, shivering


weight loss

Less common

Acid or sour stomach




red streaks on the skin

stomach discomfort or upset

swelling, tenderness, or pain at the injection site

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

wrinkled skin


Burning, dry, or itching eyes

discharge or excessive tearing

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

throbbing pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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