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Vorinostat
Specialty Drug

Zolinza

VORINOSTAT is a chemotherapy drug. It is used to treat cutaneous T-cell lymphoma (CTCL). Compare HDAC inhibitors.
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Vorinostat Side Effects

What should I watch for?

Visit your doctor for regular check ups. Report any side effects. You will need blood work done while you are taking this medicine.

Talk to your doctor about how many glasses of water to drink each day. It is important to drink plenty of fluids and to avoid dehydration.

If the capsules of this medicine is broken or opened, do not touch the capsules or the powder contents of the capsules. If the powder gets on your skin or in your eyes, wash the area well with plenty of water. Call your doctor.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxiety

black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

body aches or pain

chest pain

chills

confusion

convulsions

cough

decreased urine

diarrhea

dizziness or lightheadedness

dry mouth

ear congestion

fainting

fast heartbeat

fever

headache

increased thirst

irregular heartbeat

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

loss of voice

lower back or side pain

mood changes

muscle pain or cramps

nasal congestion

nausea or vomiting

no blood pressure

no breathing

no pulse

numbness or tingling in the face, arms, or legs

numbness or tingling in the hands, feet, or lips

pain, redness, or swelling in the arm or leg

painful or difficult urination

pale skin

pinpoint red spots on the skin

rapid weight gain

runny nose

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sudden shortness of breath or troubled breathing

swollen glands

trouble speaking, thinking, or walking

troubled breathing with exertion

unusual bleeding or bruising

unusual drowsiness, dullness, or feeling of sluggishness

unusual tiredness or weakness

Less common

Persistent non-healing sore

pink growth

reddish patch or irritated area

shiny bump

white, yellow, or waxy scar-like area

Rare

Chest discomfort

general feeling of illness

hoarseness

indigestion

pain or discomfort in the arms, jaw, back, or neck

rapid, shallow breathing

severe nausea or vomiting

sneezing

stomach pain

sweating

tightness in the chest

vomiting of blood or material that looks like coffee grounds

wheezing

yellow skin and eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Change in taste

cracks in the skin

difficulty having a bowel movement (stool)

hair loss or thinning of the hair

itching skin

lack or loss of strength

loss of heat from the body

loss of taste

muscle spasm

red, swollen skin

scaly skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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