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Specialty Drug
NALTREXONE is used to treat certain types of drug dependence. The lowest GoodRx price for the most common version of Vivitrol is around $1,308.39, 19% off the average retail price of $1,625.25. Compare opioid antagonists.
Prescription Settings
1 vial of 380mg/vial
1 carton
1 vial of 380mg/vial
1 carton

Vivitrol Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine.

Visit your doctor or health care professional regularly. It is important to attend any counseling or support groups that your doctor or health care professional recommends. Attending these sessions while you are taking this medicine will help you overcome your dependence on alcohol or narcotics (opioids). Never try to overcome the effects of the medicine by taking large amounts of narcotics (opioids) because this can cause severe problems including death. Also, you may be more sensitive to lower doses of opioids after you stop taking this medicine.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.

Do not treat yourself for coughs, colds, pain, or diarrhea. Ask your doctor or health care professional for advice. Some of the ingredients may interact with this medicine and cause side effects.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

body aches or pain




difficulty with breathing


dryness or soreness of the throat

ear congestion


feeling sad or empty





lack of appetite

loss of interest or pleasure

loss of voice

nasal congestion



runny nose


sore throat

tender, swollen glands in the neck

trouble concentrating

trouble sleeping

trouble swallowing

unusual tiredness or weakness

voice changes

Incidence not known

Abdominal or stomach cramps or pain

arm, back, or jaw pain

black, tarry stools

bladder pain


bloody or cloudy urine

bloody stools

blurred vision

chest pain or discomfort

chest tightness or heaviness



confusion as to time, place, or person



cough producing mucus

decreased urination


difficult, burning, or painful urination

dilated neck veins

dizziness or lightheadedness

dry mouth

extreme fatigue


false or unusual sense of well-being

fast, irregular, pounding, or racing heartbeat or pulse

frequent urge to urinate

general feeling of discomfort or illness

hallucinations or seeing, hearing, or feeling things that are not there

headache, severe and throbbing

holding false beliefs that cannot be changed by fact


increase in heart rate

increase in white blood cells


irregular breathing


itching, pain, redness, swelling, tenderness, or warmth on the skin

joint or muscle pain


lower back or side pain



numbness or tingling of the face, hands, or feet

pain or discomfort in the arms, jaw, back, or neck

pain, redness, or swelling in the arm or leg

pounding in the ears

rapid breathing

redness and soreness of the eyes



severe nausea or vomiting



skin rash

slow or fast heartbeat

sores in the mouth

stomach cramps or pain

sudden shortness of breath or troubled breathing

sunken eyes


swelling of the face, fingers, feet, or lower legs

swollen, painful, or tender lymph glands in the neck, armpit, or groin



tightness in the chest

tooth or gum pain

unusual excitement, nervousness, or restlessness


vomiting of blood or material that looks like coffee grounds

watery or bloody diarrhea

weight gain

wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty with moving

muscle stiffness

swelling or redness in the joints

Incidence not known

Bleeding after defecation

bloated or full feeling

change in taste

decreased interest in sexual intercourse


excess air or gas in the stomach or intestines

feeling of warmth

feeling unusually cold


inability to have or keep an erection

increased sweating

loss in sexual ability, desire, drive, or performance

loss of taste

night sweats

passing gas

redness of the face, neck, arms, and occasionally, upper chest

relaxed and calm


sudden sweating


uncomfortable swelling around anus

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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