Trintellix

Trintellix (vortioxetine) may increase your risk of suicidal thoughts or behavior, especially in people under the age of 25. Watch out for worsening depression or any unusual changes in your mood or behavior, especially during the first few months of treatment or with a dose change. Talk to a healthcare provider if you experience any of these symptoms, and seek urgent care if needed.

Some people taking Trintellix (vortioxetine) have developed a rare, but potentially life-threatening condition called serotonin syndrome. This condition happens where there's too much serotonin in the brain. Your risk for serotonin syndrome is higher if you use Trintellix (vortioxetine) with other medications that can raise your serotonin levels, such as certain antidepressants, mental health medications, pain medications, and migraine medications. Get medical help right away if you experience symptoms of serotonin syndrome, including fast heart rate, sweating, muscle stiffness or spasms, fever, and confusion.

Taking Trintellix (vortioxetine) with non-steroidal anti-inflammatory drugs (e.g., ibuprofen (Advil), naproxen (Aleve), aspirin), warfarin (Coumadin), or other medications that affect blood clotting can raise your risk of abnormal bleeding and bruising. Let your provider know if you take any of these medications before starting Trintellix (vortioxetine). Get medical help right away if you have bleeding that's difficult to stop, bruising that doesn't go away, vomit blood, or have black and tarry stool - these might be symptoms of a serious bleed.

In some people, medications like Trintellix (vortioxetine) can trigger a manic episode (high energy, trouble sleeping, racing thoughts, unusually grand ideas, reckless behavior, extreme happiness or irritability, talking faster or louder than usual). Let your provider know if you've had any manic episodes in the past, or were treated for bipolar disorder before taking Trintellix (vortioxetine). Before starting Trintellix (vortioxetine), your provider will check to see if you have or are at risk for bipolar disorder and make sure you receive the appropriate treatment. Talk to your provider right away if you or your loved ones notice unusual changes in your behavior.

Don't stop taking Trintellix (vortioxetine) without talking to your provider first. Doing so could cause withdrawal symptoms, including nausea, sweating, dizziness, headache, and trouble sleeping. The risk is higher if you're taking a higher dose of Trintellix (vortioxetine). If you need to stop this medication, your provider can help you slowly lower your dose before stopping if needed.

Trintellix (vortioxetine) can raise your risk of having low sodium levels in your blood (hyponatremia). Watch out for symptoms like headache, trouble focusing, memory problems, confusion, weakness, and unsteadiness. Talk to your provider if you experience any of these symptoms, and seek urgent care if needed.

Trintellix (vortioxetine) can lead to or worsen angle-closure glaucoma. You might need to see your optometrist (eye provider) regularly and get eye exams to check your eyes and make sure your vision isn't worsening. Contact your provider if you notice changes in your vision after starting Trintellix (vortioxetine).