Trametinib Side Effects
What should I watch for?
Visit your doctor or health care professional for regular checks on your progress.
Tell your doctor or health care professional right away if you have any change in your eyesight.
Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 4 months after stopping it.
This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Bleeding from the rectum or bloody stools
blemishes on the skin
blistering, crusting, irritation, itching, or reddening of the skin
bloating or swelling of the face, arms, hands, lower legs, or feet
chest discomfort or pain
cracked, dry, or scaly skin
coughing up blood
decreased urine output
difficulty with breathing or swallowing
dilated neck veins
extreme tiredness or weakness
fast, slow, irregular, or pounding heartbeat
increased menstrual flow or vaginal bleeding
lightheadedness, dizziness, or fainting
pounding in the ears
prolonged bleeding from cuts
rapid weight gain
red or black, tarry stools
red or dark brown urine
redness, swelling, or pain of the skin
scaling of the skin on the hands and feet
tightness in the chest
tingling of the hands and feet
ulceration of the skin
unusual tiredness or weakness
unusual weight gain or loss
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
change in taste
loosening of the fingernails
loss of taste
muscle cramp, pain, stiffness, or spasm
redness or soreness around the fingernails
sores, ulcers, or white spots on the lips or tongue or inside the mouth
swelling or inflammation of the mouth
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.