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THIOTEPA is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat many types of cancer like breast cancer, ovarian cancer, and bladder cancer and to treat fluid build-up caused by some cancers. It is also used to reduce the risk of graft rejection after a bone morrow transplant in pediatric patients with beta-thalassemia. Compare alkylating drugs.

Potentially Unavailable: This drug has recently experienced shortages and may not be available at your pharmacy. Please call ahead to confirm availability. Learn More

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Tepadina Side Effects

What should I watch for?

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

You may need blood work done while you are taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

Do not become pregnant while taking this medicine or for 6 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 year after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This medicine may interfere with the ability to have a child. Talk with your doctor or health care professional if you are concerned about your fertility.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bleeding gums

blood in the urine

blurred or double vision

confusion

coughing up blood

cracked lips

diarrhea

difficulty with breathing or swallowing

difficulty with walking

dizziness

drooping eyelids

headache, sudden, severe

increased menstrual flow or vaginal bleeding

jaw pain

nausea and vomiting

nosebleeds

numbness or tingling in the fingers and toes

pain in the fingers and toes

paralysis

prolonged bleeding from cuts

red or black, tarry stools

red or dark brown urine

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

weakness

Incidence not known

Absent, missed, or irregular menstrual periods

blistering, peeling, or loosening of the skin

bloated abdomen

cough or hoarseness

fast heartbeat

fever or chills

hives or welts, itching, or skin rash

joint or muscle pain

lower back or side pain

pain and fullness in the right upper abdomen or stomach

painful or difficult urination

pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

redness of the skin

stopping of menstrual bleeding

tightness in the chest

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

weight gain

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abdominal or stomach pain

blistering, burning, crusting, dryness, or flaking of the skin

hair loss or thinning of the hair

itching, scaling, severe redness, soreness, or swelling of the skin

loss of appetite

pain at the injection site

stopping of menstrual bleeding

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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