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HYLAN G-F 20 (HI lan G F 20) is used to treat osteoarthritis of the knee. It lubricates and cushions the joint, reducing pain in the knee. Compare viscosupplements.

Insurance Coverage: Many major insurance plans no longer cover Synvisc One starting in 2016. Learn More

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Synvisc One Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your condition will be monitored carefully while you are receiving this medicine. Most persons get pain relief for up to 6 months after treatment.

Avoid strenuous activities (high-impact sports, jogging) or major weight-bearing activities for 48 hours after the injection.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Difficulty with moving

fluid build up around the knee

muscle pain or stiffness

pain and stiffness in the joints

Less common

Bleeding after defecation

bluish color

changes in skin color

fainting

fast, pounding, or irregular heartbeat or pulse

pain or aching in the lower legs

swelling of the ankles, feet, or legs

tenderness

uncomfortable swelling around the anus

warmth or swelling of the joints

Rare

Redness in the joints

trouble with walking

Incidence not known

Black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

difficulty with breathing

feeling of warmth

general feeling of discomfort or illness

muscle cramps

pinpoint red spots on the skin

rapid weight gain

redness of the face, neck, arms, and occasionally, upper chest

shortness of breath

tingling of the hands or feet

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Itching of the skin

rash

sprain in the lower back

Rare

Pain at the injection site

Incidence not known

Dizziness

headache

nausea

raised red swellings on the skin, lips, tongue, or in the throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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