Insurance Coverage: Many major insurance plans no longer cover Synvisc One starting in 2016. Learn More
What should I watch for?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your condition will be monitored carefully while you are receiving this medicine. Most persons get pain relief for up to 6 months after treatment.
Avoid strenuous activities (high-impact sports, jogging) or major weight-bearing activities for 48 hours after the injection.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Difficulty with moving
fluid build up around the knee
muscle pain or stiffness
pain and stiffness in the joints
Bleeding after defecation
changes in skin color
fast, pounding, or irregular heartbeat or pulse
pain or aching in the lower legs
swelling of the ankles, feet, or legs
uncomfortable swelling around the anus
warmth or swelling of the joints
Redness in the joints
trouble with walking
Incidence not known
Black, tarry stools
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
difficulty with breathing
feeling of warmth
general feeling of discomfort or illness
pinpoint red spots on the skin
rapid weight gain
redness of the face, neck, arms, and occasionally, upper chest
shortness of breath
tingling of the hands or feet
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Itching of the skin
sprain in the lower back
Pain at the injection site
Incidence not known
raised red swellings on the skin, lips, tongue, or in the throat
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.