Stagesic (hydrocodone / acetaminophen) was an opioid / acetaminophen combination used to treat moderate to severe pain, but has been discontinued because it contained more than 325 mg of acetaminophen per dose.

Stagesic Side Effects

Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common



Incidence not known

Back, leg, or stomach pains

black, tarry stools

bleeding gums

blood in the urine or stools

blood in vomit

bluish lips or skin



cough or hoarseness

dark urine

decrease in the frequency of urination

decrease in urine volume

difficult or troubled breathing

difficulty in passing urine (dribbling)

difficulty with breathing

difficulty with swallowing

fast heartbeat


fever with or without chills

general body swelling

general feeling of tiredness or weakness


irregular, fast or slow, or shallow breathing

light-colored stools

loss of appetite

lower back or side pain

nausea or vomiting


not breathing

painful or difficult urination

pale or blue lips, fingernails, or skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe or continuing stomach pain

skin rash, hives, or itching

sore throat

sore tongue

sores, ulcers, or white spots on the lips or in the mouth

tightness in the chest

unable to speak

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Bloody or cloudy urine

change in consciousness

chest pain or discomfort

cold and clammy skin

decreased awareness or responsiveness

extreme drowsiness

general feeling of discomfort or illness

increased sweating

irregular heartbeat

lightheadedness, dizziness, or fainting

loss of consciousness

no blood pressure or pulse

no muscle tone or movement

not breathing

severe sleepiness

slow or irregular heartbeat

stopping of heart

sudden decrease in the amount of urine


unpleasant breath odor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


relaxed and calm


Incidence not known


changes in mood

difficulty having a bowel movement (stool)

fear or nervousness

feeling of indigestion

hearing loss

impaired hearing

pain in the chest below the breastbone

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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