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Sorafenib
Specialty Drug

Nexavar

SORAFENIB is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat liver cancer, kidney cancer, and thyroid cancer. Compare kinase inhibitors.
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Sorafenib Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Men and women should use effective birth control while taking this medicine and for 2 weeks after stopping this medicine. Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

bleeding gums

bloating of the abdomen or stomach

blood in the urine or stools

blurred vision

clay-colored stools

coughing up blood

dark urine

difficulty with breathing or swallowing

dizziness

headache

increased menstrual flow or vaginal bleeding

light-colored stools

nausea and vomiting

nervousness

nosebleeds

paralysis

pounding in the ears

prolonged bleeding from cuts

red or black, tarry stools

red or dark brown urine

slow or fast heartbeat

vomiting of blood

yellow eyes or skin

Less common

Bone pain

chest pain or discomfort

chills

clammy skin

confusion

constipation

convulsions (seizures)

cough

decreased urine production

depressed mood

difficulty with moving

dry skin and hair

enlarged pupils

feeling cold

fever

hair loss

hearing loss

hives

hoarseness or husky voice

increased sensitivity of the eyes to light

increased sweating, possibly with fever or cold

increased thirst

indigestion

itching

joint pain

loss of appetite

lower back or side pain

muscle cramps and stiffness

muscle pain

pain or discomfort in the arms, jaw, back, or neck

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

pinpoint red spots on the skin

reddening of the skin, especially around the ears

ringing, buzzing, or other unexplained noise in the ears that continues

severe chest pain

severe headache

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiff or sore neck

stomach discomfort or upset

sweating

swelling of the ankles or hands

swelling of the eyes, face, or inside of the nose

swollen glands

swollen joints

trouble breathing with exertion

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

weight gain

Incidence not known

Blistering, peeling, or loosening of the skin

diarrhea

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

red skin lesions, often with a purple center

red, irritated eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blistering, peeling, redness, and/or swelling of the palms of the hands or bottom of the feet

burning, tingling, numbness or pain in the hands, arms, feet, or legs

numbness, pain, tingling, or unusual sensations in palms of the hands or bottom of the feet

sensation of pins and needles

stabbing pain

thinning of the hair

tightness in the chest

weight loss

Less common

Acid or sour stomach

acne

belching

blistering, peeling, or loosening of the skin

burning feeling in the chest or stomach

burning, itching, and pain in hairy areas

cracked lips

cracks in the skin

decreased appetite

decreased interest in sexual intercourse

discouragement

dry mouth

fainting

feeling of warmth

feeling sad or empty

flushing or red skin

gas

general feeling of discomfort or illness

heartburn

inability to have or keep an erection

increase in heart rate

irritability

lack or loss of strength

lightheadedness

loss in sexual ability, desire, drive, or performance

loss of ability to use or understand speech or language

loss of heat from the body

loss of interest or pleasure

mouth pain

pus at the root of the hair

rapid breathing

red face, neck, arms, and occasionally, upper chest

red, swollen skin

runny nose

scaly skin

shivering

skin rash that is encrusted, scaly, and oozing

sunken eyes

swelling of the breasts or breast soreness in both men and women

swelling or inflammation of the mouth

tenderness in the stomach area

thirst

trouble concentrating

trouble sleeping

unusually warm skin

wrinkled skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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