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Quinupristin and DalfopristinSynercid
DALFOPRISTIN; QUINUPRISTIN is a streptogramin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections. Compare streptogramin antibiotics.
Prescription Settings
1 vial
1 vial

Quinupristin and Dalfopristin Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Swelling, redness, or pain at the injection site

Less common

Changes in skin color

dry, red, hot, or irritated skin

joint pain

muscle pain


redness, burning sensation, or pain under the skin usually in the injection site

swelling of the foot or leg





back, leg, or stomach pains

black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine

bloody, black, or tarry stools

blue lips, fingernails, or skin

blurred vision

bone pain

burning, tingling, numbness, or pain in the hands, arms, feet, or legs

chest pain or discomfort

chest pain, possibly moving to the left arm, neck, or shoulder





convulsions or seizures

cough or hoarseness

darkened urine

decreased urine output

difficult, fast, or labored breathing

difficult or painful urination

difficulty with moving

difficulty with swallowing


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


extremely shallow or slow breathing


fast, slow, irregular, pounding, or racing heartbeat or pulse

feeling of warmth or heat

flushing or redness of the skin, especially on the face and neck

general body swelling

general tiredness and weakness



high fever


inability to speak

increased thirst




light-colored stools

loss of appetite

loss of bladder control

loss of consciousness

loss of strength or energy

lower back or side pain

muscle pain or cramps

muscle stiffness or weakness

nausea or vomiting

no blood pressure or pulse


not breathing

pain in the joints

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

problems with bleeding or clotting

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

redness, burning sensation, or pain in the vagina

sensation of pins and needles

severe bloody diarrhea

severe or sudden headache

shakiness in the legs, arms, hands, or feet

shortness of breath

skin rash

skin rash with red patches

slurred speech

sore throat

sores on the skin

sores, ulcers, or white spots on the lips or in the mouth

stabbing pain

stiff neck

stopping of the heart


swelling of the face, ankles, or hands

swollen glands

temporary blindness

tightness in the chest

tingling of the hands or feet

total body jerking

trembling or shaking of the hands or feet

troubled breathing


unexplained bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

upper right abdominal or stomach pain


vomiting of blood or material that looks like coffee grounds

weakness in the arm or leg on one side of the body, sudden and severe


worsening of the underlying disease

yellowing of the eyes or skin

Incidence not known

Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Acid or sour stomach

ankle, knee, or great toe joint pain


cold sweats

cool, pale skin

cramps in the legs


excessive muscle tone


hives or welts

increased hunger

itching of the vagina or genital area

joint stiffness or swelling

lower back or side pain

muscle tension or tightness


pain during sexual intercourse

redness of the skin



stomach discomfort, upset, or pain


swelling or inflammation of the mouth

thick, white vaginal discharge with no odor or with a mild odor

trouble sleeping

unable to sleep

white patches in the mouth, tongue, or throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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