Premphase (conjugated estrogens; medroxyprogesterone) is used as hormone replacement in menopausal women who still have their uterus, treat hot flashes and prevent osteoporosis. This drug is slightly less popular than other estrogen/progestin combinations.There are currently no generic alternatives to Premphase.
GoodRx has partnered with InsideRx and Pfizer to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Premphase is covered by most Medicare and insurance plans.
Premphase Side Effects
What should I watch for?
Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.
If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine
clear or bloody discharge from the nipple
cough or hoarseness
dimpling of the breast skin
fast, irregular, pounding, or racing heartbeat or pulse
feeling faint, dizzy, or lightheaded
feeling of warmth or heat
fever or chills
flushing or redness of the skin, especially on the face and neck
lower back or side pain
lump in the breast or under the arm
pain during sexual intercourse
painful or difficult urination
persistent crusting or scaling of the nipple
pounding in the ears
redness or swelling of the breast
severe cramping of the uterus
sore on the skin of the breast that does not heal
thick, white vaginal discharge with no odor or with a mild odor
tingling of the hands or feet
unusual weight gain or loss
vaginal bleeding that is unusual and heavy
vaginal or genital itching
vaginal yeast infection
Incidence not known
Absent, missed, or irregular menstrual periods
acid or sour stomach
breast pain or tenderness
decreased vision or other changes in vision
difficulty with speaking
inability to move the arms, legs, or facial muscles
inability to speak
loss of appetite
pain or discomfort in the arms, jaw, back, or neck
pain or feeling of pressure in the pelvis
pain, redness, or swelling in the arm or leg
painful or tender cysts in the breasts
pains in the stomach, side, or abdomen, possibly radiating to the back
sudden shortness of breath or troubled breathing
unexpected or excess milk flow from the breasts
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Blemishes on the skin
body aches or pain
difficulty with moving
dryness of the vagina
excessive muscle tone
fullness or swelling of the breasts
hair loss or thinning of the hair
headache, severe and throbbing
loss of bladder control
menstrual periods that are longer or heavier
muscle pain or stiffness
pain in the joints
pain or tenderness around the eyes and cheekbones
quick to react or overreact emotionally
rapidly changing moods
sore mouth or tongue
stuffy or runny nose
tender, swollen glands in the neck
tightness of the chest or wheezing
trouble with sleeping
trouble with swallowing
vaginal discharge that is clear or white
white patches in the mouth or on the tongue
Incidence not known
Changes in appetite
hives or welts
inability to have or keep an erection
increased hair growth, especially on the face
increased interest in sexual intercourse
loss in sexual ability, desire, drive, or performance
loss of scalp hair
pain in the ankles or knees
painful, red lumps under the skin, mostly on the legs
patchy brown or dark brown discoloration of the skin
redness of the skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.