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Type your drug name (like Atorvastatin, Sildenafil, etc)
Iclusig Coupon - Iclusig 15mg tablet
Specialty Drug
PONATINIB is a medicine that targets proteins in cancer cells and stops the cancer cell from growing. It is used to treat chronic myelogenous leukemia and certain types of acute lymphoblastic leukemia. Compare kinase inhibitors.
Prescription Settings
30 tablets
Iclusig Coupon - Iclusig 15mg tablet
30 tablets

Ponatinib Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

You may need blood work done while you are taking this medicine.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

Do not become pregnant while taking this medicine or for 3 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 6 days after stopping it.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bladder pain

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

chest pain


cloudy urine



cough or hoarseness

coughing up blood

decreased urine output

difficult, burning, or painful urination

difficulty with breathing or swallowing

dilated neck veins


extreme fatigue


frequent urge to urinate

increased menstrual flow or vaginal bleeding


irregular breathing

joint pain, stiffness, or swelling


lower back, side, or stomach pain



pains in the chest, groin, or legs, especially calves of the legs

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin


pinpoint red spots on the skin

pounding in the ears

prolonged bleeding from cuts

rapid weight gain

rapid, shallow breathing

red or black, tarry stools

red or dark brown urine

severe headaches of sudden onset

slow or fast heartbeat

sore throat

sudden loss of coordination

sudden shortness of breath

sudden slurred speech

sudden vision changes

tingling of the hands or feet

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual weight gain or loss

Less common


burning, numbness, tingling, or painful sensations

chest pain or discomfort

fast, pounding, or irregular heartbeat or pulse

pain, redness, or swelling in the arms or legs

sudden shortness of breath

unsteadiness or awkwardness

weakness in the arms, hands, legs, or feet

Incidence not known

Abdominal or stomach cramps or tenderness

blue-green halos seen around objects

clay-colored stools

dark urine

decreased appetite


dry eyes



itching or skin rash

loss of appetite

nausea and vomiting

sensitivity of the eyes to light

severe vomiting, sometimes with blood

unusual tiredness or weakness

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back or bone pain

cracked lips

difficulty having a bowel movement (stool)

difficulty with moving

dry skin

itching, pain, redness, swelling, tenderness, or warmth on the skin

lack or loss of strength

muscle aches

muscle pain or stiffness

sore throat

stuffy or runny nose

trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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