Pexidartinib Side Effects
What should I watch for?
Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.
May need blood work while you are taking this medication.
This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps, tanning beds, or tanning booths.
Talk to your care team if you or your partner may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 1 month after the last dose. You will need a negative pregnancy test before starting this medication. Estrogen and progestin hormones may not work as well while you are taking this medication. Contraception is recommended while taking this medication and for 1 month after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication and for at least 1 week after the last dose.
If your partner can get pregnant, use a condom during sex while taking this medication and for 1 week after the last dose. Tell your care team right away if you think your partner might be pregnant. This medication can cause serious birth defects.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.
What are the side effects?
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Change in hair color
- Change in taste
- Fatigue
- Loss of appetite
- Swelling around the eyes
- Swelling of the ankles, hands, or feet
- Vomiting
What may interact with this drug?
Do not take this medication with any of the following:
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Lonafarnib
- Mavacamten
- Ranolazine
This medication may also interact with the following:
- Certain medications for stomach problems, such as lansoprazole, omeprazole, pantoprazole
- Estrogen or progestin hormones
- Grapefruit juice
- Other medications that cause liver problems
- St. John's Wort
Take this medication 2 hours before or 2 hours after antacids to avoid decreasing its absorption.
Take this medication 2 hours before or 10 hours after H2 receptor blockers to avoid decreasing its absorption.