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Perphenazine / Amitriptyline Coupon - Perphenazine / Amitriptyline 2mg/25mg tablet

Generic Triavil, Etrafon

PERPHENAZINE; AMITRIPTYLINE is used to treat depression that may be accompanied by anxiety or agitation. This medicine is also used to treat schizophrenia. Compare typical antipsychotic / tricyclic antidepressant combinations.
Perphenazine / Amitriptyline Coupon - Perphenazine / Amitriptyline 2mg/25mg tablet
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Perphenazine / Amitriptyline Side Effects

What should I watch for?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

This medicine can cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

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Common and Rare Side Effects

Along with its needed effects, perphenazine (included in this combination medicine) can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Rare

Convulsions (seizures)

difficulty in breathing

fast heartbeat

fever

high or low blood pressure

increased sweating

loss of bladder control

muscle stiffness (severe)

unusual tiredness or weakness

unusually pale skin

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Blurred vision or any change in vision

difficulty in speaking or swallowing

fainting

inability to move eyes

lip smacking or puckering

loss of balance control

mask-like face

muscle spasms, especially of face, neck, and back

nervousness, restlessness, or need to keep moving

puffing of cheeks

rapid or fine, worm-like movements of tongue

shuffling walk

stiffness of arms and legs

trembling and shaking of fingers and hands

tic-like or twitching movements

twisting movements of body

uncontrolled chewing movements

uncontrolled movements of arms or legs

weakness of arms and legs

Less common

Confusion

constipation

difficult urination

eye pain

hallucinations (seeing, hearing, or feeling things that are not there)

increased skin sensitivity to sun

shakiness

slow pulse or irregular heartbeat

Rare

Abdominal or stomach pain

aching muscles or joints

back or leg pain

fever and chills

hair loss

hot, dry skin or lack of sweating

irritability

loss of appetite

muscle weakness or twitching

nausea, vomiting, or diarrhea

nosebleeds

prolonged, painful, inappropriate penile erection

ringing, buzzing, or other unexplained noises in ears

skin discoloration

skin rash and itching

sore throat and fever

swelling of face and tongue

swelling of testicles

unusual bleeding or bruising

yellow eyes or skin

Symptoms of overdose

Agitation

confusion

convulsions (seizures)

drowsiness (severe)

enlarged pupils

fast, slow, or irregular heartbeat

fever

hallucinations (seeing, hearing, or feeling things that are not there)

shortness of breath or troubled breathing

unusual tiredness or weakness (severe)

vomiting (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Decreased sweating

dizziness

drowsiness

dryness of mouth

headache

increased appetite for sweets

nasal congestion

tiredness or weakness (mild)

unpleasant taste

weight gain (unusual)

Less common

Changes in menstrual period

decreased sexual ability

heartburn

increased sweating

swelling or pain in breasts or unusual secretion of milk

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Dizziness

nausea or vomiting

stomach pain

trembling of fingers and hands

symptoms of tardive dyskinesia, including lip smacking or puckering, puffing of cheeks, rapid or fine, worm-like movements of tongue, uncontrolled chewing movements, or uncontrolled movements of arms or legs

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Diarrhea

headache

irritability

restlessness

trouble in sleeping, with vivid dreams

unusual excitement

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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