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Pasireotide
Specialty Drug

Signifor

PASIREOTIDE is used to reduce blood levels of cortisol in patients with a condition called Cushing's disease. It is used when surgery is not an option or has not worked well enough. Compare somatostatin analogues.
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Pasireotide Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may need blood work done while you are taking this medicine.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain or fullness

anxiety

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

chills

cold sweats

coma

confusion

convulsions

cool, pale skin

darkening of the skin

decreased urine

depression

diarrhea

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

fainting

flushed, dry skin

fruit-like breath odor

gaseous abdominal or stomach pain

headache

increased hunger

increased thirst

increased urination

irregular heartbeat

loss of appetite

loss of consciousness

muscle pain or cramps

nausea or vomiting

nightmares

numbness or tingling in the hands, feet, or lips

pounding in the ears

rapid weight gain

recurrent fever

seizures

shakiness

skin rash

slow or fast heartbeat

slurred speech

sweating

tingling of the hands or feet

troubled breathing

unexplained weight loss

unusual tiredness or weakness

unusual weight gain or loss

yellow eyes or skin

Incidence not known

Clay-colored stools

constipation

darkened urine

dry skin and hair

feeling cold

fever

hair loss

hoarseness or husky voice

indigestion

itching

loss of appetite

muscle stiffness

pains in the stomach, side, or abdomen, possibly radiating to the back

unpleasant breath odor

vomiting of blood

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

cough

decreased appetite

difficulty with moving

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

joint pain

lack or loss of strength

pain in the arms or legs

pressure in the stomach

sensation of spinning

shivering

stuffy or runny nose

sweating

swelling of the abdominal or stomach area

swollen joints

trouble sleeping

upper abdominal or stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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