Specialty Drug


NATALIZUMAB is used to treat relapsing multiple sclerosis. This drug is not a cure. It is also used to treat Crohn's disease. Compare integrin antagonists.

Natalizumab Medicare Coverage


Does Medicare cover Tysabri?

100% of Medicare Part D and Medicare Advantage plans cover this drug.

How much is my Tysabri co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…

Donut Hole
Post-Donut Hole
Co-Pay Range
$5806 – $6481
In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
Co-Pay Range
$1452 – $6330
In the Typical co-pay stage, your deductible has been satisfied, and Medicare pays the majority of your drug costs.
Co-Pay Range
$1966 – $2944
In the Donut Hole (also called the Coverage Gap) stage, you’ll pay more for your prescriptions. In 2016, the Donut Hole begins once you’ve spent $3,310 in one year.
Co-Pay Range
$290 – $327
In the Post-Donut Hole (also called Catastrophic Coverage) stage, Medicare will cover most of your drug costs. In 2016, this stage begins once you have spent $4,850.
Want an exact price for your co-pay?

Ways to Save on Natalizumab

Here are some ways that may lower the cost of your Tysabri prescription.

Patient Assistance Program
Call to get more information on how they can financially assist you with your prescription.
Patient Assistance Program
Call to get more information on how they can financially assist you with your prescription.

Find Your Natalizumab Medicare Co-Pay

Here are average co-pays for some of the most popular Medicare plans. Be sure to add your plan to see your specific co-pay. If a price is shown in red, GoodRx has found discount prices that are lower than your Medicare co-pay.

Average Co-Pay for 1 vial (15ml) of Tysabri 300mg/15ml

Medicare Plan Name Average Co-Pay
AARP MedicareRx Preferred (PDP)Lower price available $2498
AARP MedicareRx Saver Plus (PDP)Lower price available $1573
AARP MedicareRx Walgreens (PDP)Lower price available $1546
Aetna Medicare Rx Saver (PDP)Lower price available $1542
Anthem Blue Cross MedicareRx Plus (PDP)Lower price available $1982
Anthem MediBlue Essential (HMO)Lower price available $1863
CareMore Value Plus (HMO)Lower price available $3438
Cigna-HealthSpring Preferred (HMO)Lower price available $1779
EnvisionRxPlus (PDP)Lower price available $1553
Express Scripts Medicare - Choice (PDP)Lower price available $1576
Express Scripts Medicare - Value (PDP)Lower price available $1515
First Health Part D Value Plus (PDP)Lower price available $2036
Humana Enhanced (PDP)Lower price available $1947
Humana Preferred Rx Plan (PDP)Lower price available $1475
Humana Walmart Rx Plan (PDP)Lower price available $1475
Kaiser Permanente Medicare Plus Std w/Part D (AB) (Cost)Lower price available $2006
MedicareBlue Rx Standard (PDP)Lower price available $1544
SilverScript Plus (PDP)Lower price available $2049
Symphonix Value Rx (PDP)Lower price available $1575
TexanPlus Classic (HMO)Lower price available $5037
Don't see your Medicare plan above?

Find and configure your plan to see exact co-pay prices for your meds.

Natalizumab Medicare Formulary Information & Restrictions

Are there any restrictions on coverage?

Some Medicare plans have restrictions on coverage of Tysabri that may include:

Prior Authorization

Most Medicare plans will require you to obtain their authorization before they will provide coverage for this prescription. You’ll need to contact your plan and they may require you to have your doctor fill out paperwork indicating why you need this prescription. If you do not receive authorization or don’t want to go through this process, you may want to consider using a GoodRx discount instead of Medicare to find the best price for this prescription.

What drug tier is Tysabri typically on?

Tier 5

Medicare plans typically list Tysabri in Tier 5 of their formulary. Tier 5 drugs are usually non-preferred brand-name drugs. Tier 5 drugs cost more than Tier 1, 2, 3 and 4 drugs.

Does your plan have restrictions?

See discount prices that can save you money when your Medicare plan doesn't work for you.

Medicare prices are provided by the Centers for Medicare and Medicaid Services (CMS). They are accurate as-of January 2017 and the information may be updated. If you encounter any issues, please let us know.
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