What is the difference between Milprosa (progesterone) and other forms of vaginal progesterone?

Milprosa (progesterone) contains progesterone, which is commonly used to help females become and stay pregnant. Progesterone comes in many different forms, including a vaginal insert ([Endometrin](https://www.goodrx.com/endometrin/what-is)) and a vaginal gel ([Crinone](https://www.goodrx.com/crinone/what-is)). Endometrin and Crinone are inserted vaginally, like Milprosa (progesterone), but they have to be used more often. Endometrin is typically used 2 to 3 times a day and Crinone is typically used 1 to 2 times a day. The advantage to using Milprosa (progesterone) is that after you insert it, it only needs to be replaced every 7 days. But some people might find Milprosa (progesterone) more difficult to use than these other products since the ring has to be inserted in the vagina and then removed.

Can I use Milprosa (progesterone) with other vaginal products?

No, it's not recommended to use Milprosa (progesterone) with other vaginal products (i.e., antifungal creams, lubricants, diaphragms, and condoms). Using these products with Milprosa (progesterone) could change the way progesterone is released and absorbed from the ring, which could cause it to not work as well. Milprosa (progesterone) can be removed during sex, but it doesn't have to be.

Milprosa

Q: What is Milprosa (progesterone)?

Milprosa (progesterone) is a vaginal ring that contains progesterone. It's used in females undergoing [in vitro fertilization (IVF)](https://www.goodrx.com/conditions/fertility/is-in-vitro-fertilization-right-for-you), a type of treatment used to become pregnant. Higher levels of progesterone raise the likelihood of an embryo successfully implanting in the lining of the uterus (womb) to start the pregnancy. Progesterone also helps you stay pregnant once an embryo is implanted. One Milprosa (progesterone) ring releases a steady amount of progesterone every day over 1 week. It's typically started on the day after an egg retrieval. You'll leave one ring in place for 7 days, then remove the used ring and insert a new one. Milprosa (progesterone) can be used weekly for up to 10 weeks.

Q: What are the side effects of Milprosa (progesterone)?

The most common side effects of Milprosa (progesterone) are headache, vaginal discharge, nausea, stomach pain or bloating, pelvic pain, breast tenderness, discomfort after inserting the ring, and constipation.

Q: Does Milprosa (progesterone) cause any serious side effects?

Yes, Milprosa (progesterone) can raise your risk of heart attack, stroke, and blood clots. If you experience chest pain, shortness of breath, weakness or numbness on one side of the body, slurred speech, confusion, or pain and swelling in your arms or legs get medical help right away. Milprosa (progesterone) can also cause depression, especially in people with a history of depression. Talk to your provider if you notice new or worsening depression while taking this medication.

progesterone

Used for Fertility

Milprosa (progesterone) is a flexible vaginal ring that releases progesterone into the body. It helps people with infertility become and stay pregnant during treatment in an assisted reproductive technology (ART) program. Milprosa (progesterone) might be more convenient than similar treatment options because one ring is left in the vagina for 7 days.

Reviewed by:

Sarah Lobello Pearson, PharmD

Kristianne Hannemann, PharmD

Last reviewed on September 15, 2022

What is Milprosa (progesterone)?

What is Milprosa (progesterone) used for?

Infertility

Are you looking for information on progesterone (Prometrium), Crinone (progesterone) vaginal gel, or Endometrin (progesterone) vaginal insert instead?

Drug facts

Common Brands	Milprosa
Drug Class	Progesterone
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Prescription only

Common Brands

Milprosa

Drug Class

Progesterone

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Prescription only

Common questions about Milprosa

Milprosa is a vaginal ring that contains progesterone. It's used in females undergoing in vitro fertilization (IVF), a type of treatment used to become pregnant. Higher levels of progesterone raise the likelihood of an embryo successfully implanting in the lining of the uterus (womb) to start the pregnancy. Progesterone also helps you stay pregnant once an embryo is implanted. One Milprosa ring releases a steady amount of progesterone every day over 1 week. It's typically started on the day after an egg retrieval. You'll leave one ring in place for 7 days, then remove the used ring and insert a new one. Milprosa can be used weekly for up to 10 weeks.

After washing your hands, make sure you're in a comfortable position. Use your thumb and index finger to squeeze the ring. Use your index finger to push the ring up into the vagina. Before you start using Milprosa, make sure you read and understand the Instructions for Use.

Milprosa contains progesterone, which is commonly used to help females become and stay pregnant. Progesterone comes in many different forms, including a vaginal insert (Endometrin) and a vaginal gel (Crinone). Endometrin and Crinone are inserted vaginally, like Milprosa, but they have to be used more often. Endometrin is typically used 2 to 3 times a day and Crinone is typically used 1 to 2 times a day. The advantage to using Milprosa is that after you insert it, it only needs to be replaced every 7 days. But some people might find Milprosa more difficult to use than these other products since the ring has to be inserted in the vagina and then removed.

No, it's not recommended to use Milprosa with other vaginal products (i.e., antifungal creams, lubricants, diaphragms, and condoms). Using these products with Milprosa could change the way progesterone is released and absorbed from the ring, which could cause it to not work as well. Milprosa can be removed during sex, but it doesn't have to be.

The most common side effects of Milprosa are headache, vaginal discharge, nausea, stomach pain or bloating, pelvic pain, breast tenderness, discomfort after inserting the ring, and constipation.

Yes, Milprosa can raise your risk of heart attack, stroke, and blood clots. If you experience chest pain, shortness of breath, weakness or numbness on one side of the body, slurred speech, confusion, or pain and swelling in your arms or legs get medical help right away. Milprosa can also cause depression, especially in people with a history of depression. Talk to your provider if you notice new or worsening depression while taking this medication.