Midostaurin Side Effects
What should I watch for?
You may need blood work done while you are taking this medicine.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Do not become pregnant while taking this medicine or for at least 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for at least 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for at least 4 months after stopping it.
This medicine may interfere with the ability to have a child. Talk with your doctor or health care professional if you are concerned about your fertility.
Side Effects to watch for
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- chest pain or chest tightness
- low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
- shortness of breath
- signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
- signs and symptoms of high blood sugar such as dizziness; dry mouth; dry skin; fruity breath; nausea; stomach pain; increased hunger or thirst; increased urination
- signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
- signs of decreased red blood cells - unusually weak or tired, feeling faint or lightheaded, falls
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
What may interact with this drug?
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
- certain medicines for HIV or AIDS like boceprevir, cobicistat, danoprevir, elvitegravir, indinavir, lopinavir/ritonavir, nelfinavir, paritaprevir/ritonavir (and ombitasvir and/or dasabuvir), ritonavir, saquinavir, and tipranavir
- certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
- certain medicines for seizures like carbamazepine and phenytoin
- grapefruit juice
- other medicines that prolong the QT interval (cause an abnormal heart rhythm)
- St. John's Wort