Megestrol Side Effects
What should I watch for?
Visit your doctor or health care professional for regular checks on your progress. Continue taking this medicine even if you feel better. It may take 2 months of regular use before you know if this medicine is working for your condition.
If you are a female of child-bearing age, use an effective method of birth control while you are taking this medicine. This medicine should not be used by females who are pregnant or breast-feeding. There is a potential for serious side effects to an unborn child or to an infant. Talk to your health care professional or pharmacist for more information.
If you have diabetes, this medicine may affect blood sugar levels. Check your blood sugar and talk to your doctor or health care professional if you notice changes.
Common and Rare Side Effects
Along with their needed effects, progestins used in high doses sometimes cause some unwanted effects such as blood clots, heart attacks, and strokes, or problems of the liver and eyes. Although these effects are rare, some of them can be very serious and cause death. It is not clear if these problems are due to the progestin. They may be caused by the disease or condition for which progestins are being used.
The following side effects may be caused by blood clots. Although not all of these side effects may occur, if they do occur they need immediate medical attention.
Get emergency help immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
Changes in vaginal bleeding (increased amounts of menstrual bleeding occurring at regular monthly periods, lighter vaginal bleeding between menstrual periods, heavier vaginal bleeding between regular monthly periods, or stopping of menstrual periods)
unexpected or increased flow of breast milk
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Abdominal pain or cramping
bloating or swelling of ankles or feet
blood pressure increase (mild)
drowsiness (progesterone only)
pain or irritation at place of injection site
swelling of face, ankles, or feet
unusual or rapid weight gain
breast pain or tenderness
brown spots on exposed skin, possibly long-lasting
loss or gain of body, facial, or scalp hair
loss of sexual desire
trouble in sleeping
Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. All of the progestins are similar, so any of the above side effects may occur with any of these medicines.
After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice the following side effect:
Delayed return to fertility
stopping of menstrual periods
unusual menstrual bleeding (continuing)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.