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Leuprolide and Norethindrone

LEUPROLIDE; NORETHINDRONE is a combination of 2 medicines that help to treat endometriosis in women. Leuprolide is an injection that acts like a natural hormone in the body. Norethindrone is a tablet that is a female hormone. Compare gonadotropin releasing hormone agonist / progestin combinations.

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Leuprolide and Norethindrone Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Talk to your doctor about using a method of birth control that does not contain hormones.

Using this medicine for a long time may increase your risk of low bone mass. Do not use for more than 2 six-month treatments. Talk to your doctor about bone health.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

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Side Effects to watch for

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast swelling, tenderness
breathing problems
changes in vision
depressed mood
loss of memory
pain in your legs or groin
severe headache
shortness of breath, chest pain, swelling in a leg
stomach pain
swelling of the feet and legs
unusually weak or tired
vaginal infection
visual changes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

anxious
change in menstrual flow
constipation
hot flashes
irritable
loss of appetite
muscle pain
nausea
pain, redness, or irritation at site where injected
skin problems or acne
trouble sleeping
weight gain

What may interact with this drug?

Do not take this medicine with any of the following medications:

amprenavir or fosamprenavir
bosentan
chasteberry

This medicine may also interact with the following medications:

antibiotics or medicines for infections, especially rifampin, rifabutin, rifapentine, and griseofulvin, and possibly penicillins or tetracyclines
aprepitant
barbiturate medicines, such as phenobarbital
carbamazepine
felbamate
herbal or dietary supplements, like black cohosh or DHEA
modafinil
oxcarbazepine
phenytoin
ritonavir or other medicines for HIV infection or AIDS
St. John's wort
topiramate

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