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Ipilimumab
Specialty Drug

Yervoy

IPILIMUMAB is a monoclonal antibody. It is used to treat melanoma, a type of skin cancer. Compare CTLA-4 antagonists.
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Ipilimumab Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Do not become pregnant while taking this medicine or for 3 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 3 months after the last dose.

Your condition will be monitored carefully while you are receiving this medicine.

You may need blood work done while you are taking this medicine.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bloody, black, or tarry stools

diarrhea

fever

heartburn

indigestion

itching skin

nausea

rash

severe stomach pain, cramping, or burning

unusual tiredness or weakness

vomiting

vomiting of material that looks like coffee grounds, severe and continuing

watery or bloody diarrhea

Less common

Abdominal or stomach tenderness

blistering, crusting, irritation, itching, or reddening of the skin

bloody or cloudy urine

blurred vision or other changes in vision

burning, dry, or itching eyes

burning, tingling, numbness or pain in the hands, arms, feet, or legs

chest pain

chills

clay-colored stools

cough

cracked, dry, or scaly skin

dark urine

darkening of the skin

decreased appetite

decreased frequency or amount of urine

difficulty with breathing, chewing, swallowing, or talking

dizziness

double vision

drooping eyelids

drowsiness

eye discharge or excessive tearing

eye pain or sensitivity to light

fainting

headache, possibly severe

hives or welts

loss of appetite

mental depression

muscle weakness

pain, itching, burning, swelling, bleeding, or a lump under the skin where the needle was placed

painful or difficult urination

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

sensation of pins and needles

severe tiredness

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stabbing pain

swelling of the face, feet, or lower legs

swollen glands

unusual bleeding or bruising

unusual weight gain

yellow eyes or skin

Rare

Anxiety

bloating

blue or pale skin

chest pain, possibly moving to the left arm, neck, or shoulder

confusion

constipation

difficulty with moving

fast heartbeat

general feeling of discomfort or illness

increased thirst

lower back or side pain

muscle pain or stiffness

muscle weakness

pain or burning in the throat

pain, swelling, or redness in the joints

pains in the stomach or side, possibly radiating to the back

skin irritation or rash, including rash that looks like psoriasis

sores, welting, or blisters on the skin

stiff neck or back

Incidence not known

Back, leg, or stomach pains

bleeding gums

general body swelling

inability to move the arms and legs

nosebleeds

throbbing pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Headache

trouble sleeping

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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