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Ionsys is part of the Opioids class and treats Pain. Opioids are used to treat pain, opioid dependence, and diarrhea. They work by affecting areas of the brain that sense pain and by allowing more fluid to be absorbed in the small intestine. Ionsys is only available as a brand name drug. Compare opioids.
Prescription Settings
4 patches
4 patches
Coupon Notice: This drug is a controlled substance. Note that some pharmacies may not honor coupons for controlled substances.

Ionsys Side Effects

Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common


bloating or swelling of the face, arms, hands, lower legs, or feet

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


decrease in urine volume

difficulty in breathing or swallowing

difficulty in passing urine (dribbling)

fast, irregular, pounding, or racing heartbeat or pulse

painful urination

rapid weight gain

seeing, hearing, or feeling things that are not there

skin itching, rash, or redness

swelling of the face, throat, or tongue


unusual weight gain or loss

upper stomach pain


Bluish color of the fingernails, lips, skin, palms, or nail beds

burning, itching, redness, skin rash, swelling, or soreness at the application site

confusion about identity, place, and time

false or unusual sense of well-being

irregular, fast or slow, or shallow breathing

Incidence not known


blurred vision

chest pain or discomfort


darkening of the skin


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position




lightheadedness, dizziness, or fainting

loss of appetite

mental depression



overactive reflexes

poor coordination

pounding in the ears


severe constipation

severe vomiting



talking or acting with excitement you cannot control

tightness in the chest

unusual tiredness or weakness


Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Cold, clammy skin

drowsiness that is so severe you are not able to answer when spoken to or, if asleep, cannot be awakened

pinpoint (small) pupils in the eyes


slow heartbeat

very slow or troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


feeling cold

sleepiness or unusual drowsiness

trouble sleeping

Less common

Dry mouth

feeling of constant movement of self or surroundings

feeling of crawling, tingling, or burning of the skin

lack or loss of strength

memory loss

sensation of spinning

unusual dreams


Abnormal ejaculation

decreased interest in sexual intercourse

decreased sexual performance or desire

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

muscle twitching

Incidence not known




stomach discomfort or upset

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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