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Specialty Drug

LOMUSTINE is a chemotherapy drug. It interferes with the growth of rapidly growing cells like cancer cells. This medicine is used to treat brain tumors and Hodgkin's disease. Compare alkylating drugs.

Prescription Settings

Availability: Gleostine replaces lomustine and CeeNu, which have been discontinued by the manufacturer. Learn More

Gleostine Side Effects

What should I watch for?

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine is taken only every 6 weeks. You may need to wait longer between doses if you have low blood counts. Your doctor will order blood work to check your blood count and to monitor your condition.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

This medicine may interfere with the ability to have a child. You should talk with your doctor or health care professional if you are concerned about your fertility.

Do not become pregnant while taking this medicine or for 2 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.

Common and Rare Side Effects

Along with their needed effects, medicines like lomustine can sometimes cause unwanted effects such as blood problems, loss of hair, and other side effects; these are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bleeding gums

chest pain

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Awkwardness

black, tarry stools

blood in the urine or stools

confusion

cough or hoarseness

decrease in urination

fever or chills

lower back or side pain

painful or difficult urination

pale skin

pinpoint red spots on the skin

slurred speech

swelling of the feet or lower legs

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

Incidence not known

Abdominal or stomach pain or tenderness

bone pain

change in frequency of urination or amount of urine

clay colored stools

dark urine

decreased appetite

dizziness

drowsiness

dry mouth

headache

increased blood pressure

increased thirst

itching

loss of appetite

nausea or vomiting

skin rash

weight gain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Darkening of the skin

diarrhea

Incidence not known

Blurred vision

changes in patterns and rhythms of speech

confusion about identity, place, and time

decreased vision

eye pain

hair loss or thinning of the hair

shakiness and unsteady walk

swelling or inflammation of the mouth

trouble with speaking

unsteadiness, trembling, or other problems with muscle control or coordination

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Other alkylating drugs

Avastin

Gleolan

Gliadel

Temodar

Other Conditions

Brain Tumor

Hodgkin's Disease

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