Specialty Drug
HUMAN PAPILLOMAVIRUS VACCINE is a vaccine. It is used to prevent infections of four types of the human papillomavirus. In women, the vaccine may lower your risk of getting cervical, vaginal, vulvar, or anal cancer and genital warts. In men, the vaccine may lower your risk of getting genital warts and anal cancer. You cannot get these diseases from the vaccine. This vaccine does not treat these diseases. Compare vaccinations.

Gardasil Side Effects

What should I watch for?

This vaccine may not fully protect everyone. Continue to have regular pelvic exams and cervical or anal cancer screenings as directed by your doctor.

The Human Papillomavirus is a sexually transmitted disease. It can be passed by any kind of sexual activity that involves genital contact. The vaccine works best when given before you have any contact with the virus. Many people who have the virus do not have any signs or symptoms.

Tell your doctor or health care professional if you have any reaction or unusual symptom after getting the vaccine.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


Less common

Black, tarry stools

bleeding gums

blood in urine or stools

blurred vision

body aches or pain




depressed mood

difficulty with breathing

dry mouth

dry skin and hair

ear congestion

feeling cold

flushed, dry skin

fruit-like breath odor


hoarseness or husky voice

increased hunger

increased thirst

increased urination

loss of consciousness

loss of voice

muscle cramps and stiffness

nasal congestion


pinpoint red spots on skin

runny nose

slowed heartbeat


sore throat



troubled breathing

unexplained weight loss

unusual bleeding or bruising

unusual tiredness or weakness



Difficulty with swallowing


fast heartbeat



noisy breathing

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

shortness of breath

skin rash

tightness in the chest


Incidence not known


back pain, sudden and severe

back, leg, or stomach pains


chest pain

convulsions (seizures)

dark urine


general body swelling

hives or welts


inability to move the arms and legs



joint pain, stiffness, or swelling

loss of appetite

loss of bladder control

muscle spasm or jerking of all extremities

muscle weakness, sudden and progressing


pain in the stomach, side, or abdomen, possibly radiating to the back

pain, redness, or swelling in the arm or leg

pale skin



redness of the skin

shakiness and unsteady walk, unsteadiness, trembling, or other problems with muscle control or coordination

sudden loss of consciousness

sudden numbness and weakness in the arms and legs

sudden shortness of breath or troubled breathing

swelling of the eyelids, face, lips, hands, or feet

swollen, painful, or tender lymph glands in the neck, armpit, or groin

yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Red streaks on the skin, swelling, tenderness, pain, or itching at the injection site

Less common

Changes in skin coloring

cloudy urine


difficulty with moving

general feeling of discomfort or illness

hair loss, thinning of hair

muscle pain or stiffness

pain in the joints



trouble with sleeping

unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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