EZOGABINE is used to control partial seizures in adults with epilepsy. Compare potassium channel openers.

Ezogabine Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. This medicine needs careful monitoring. Do not stop taking except on your doctor's advice.

Your vision and blood may be tested before and during use of this medicine. Tell your doctor or health care professional right away if you have any change in your eyesight. It is recommended that you receive a complete eye exam about every 6 months.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

The use of this medicine may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medicine. Any worsening of mood, or thoughts of suicide or dying should be reported to your health care professional right away.

Women who become pregnant while using this medicine may enroll in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334. This registry collects information about the safety of antiepileptic drug use during pregnancy.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Decrease in the frequency of urination

decrease in the urine volume

difficulty with passing urine (dribbling)

painful urination

shakiness in the legs, arms, hands, or feet

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine

burning while urinating

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

difficult urination

general feeling of discomfort or illness

muscle twitching or jerking

rapid weight gain

rhythmic movement of the muscles

tingling of the hands or feet

unusual tiredness or weakness

unusual weight gain or loss

Incidence not known


back pain

black, tarry stools

bleeding gums

blurred vision

change in consciousness

chest pain


cloudy urine



difficult or labored breathing







loss of consciousness

pain in the lower back or side

pinpoint red spots on the skin

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiff neck

swollen glands

tightness in the chest

unusual bleeding or bruising


Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Being forgetful

clumsiness or unsteadiness

dizziness or lightheadedness

double vision

feeling of constant movement of self or surroundings

seeing double

sensation of spinning

sleepiness or unusual drowsiness

Less common

Absence of or decrease in the body movement

acid or sour stomach


changes in patterns and rhythms of speech

confusion about identity, place, and time



difficulty having a bowel movement (stool)

difficulty with swallowing

dry mouth

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there


increased appetite

increased sweating


joint pain

lack or loss of strength

loss of appetite

loss of memory

muscle aches and pains

problems with speech or speaking

runny nose

severe mood or mental changes


slurred speech

stomach discomfort, upset, or pain


trouble sleeping

trouble walking

unusual behavior

weight gain

Incidence not known

False or unusual sense of wellbeing

hair loss or thinning of the hair

muscle spasms


uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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