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Endodan Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take the medicine for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

Too much aspirin can be very dangerous. Do not take aspirin or medicines that contain aspirin with this medicine. Many non-prescription medicines contain aspirin. Always read the labels carefully.

This medicine can irritate your stomach or cause bleeding problems. Do not smoke cigarettes or drink alcohol. Do not lie down for 30 minutes after taking this medicine to prevent irritation in your throat.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

The medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal pain, cramping, or tenderness

agitation

bleeding gums

bloating

blood in the urine or stools

bloody, black, or tarry stools

blue lips, fingernails, or skin

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in consciousness or confusion

chest pain or discomfort

chills

clay-colored stools

constipation

convulsions

coughing or vomiting blood

dark-colored urine

decrease in urine volume or frequency

decreased appetite

depression

difficult, fast, noisy breathing, sometimes with wheezing

difficulty in passing urine (dribbling)

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

dry mouth

fainting

fast, slow, irregular, pounding, or racing heartbeat or pulse

feeling of hostility or irritability

feeling of warmth

feeling that something terrible will happen

fever

headache, sudden, severe

heartburn

hives or itching

increased menstrual flow or vaginal bleeding

increased sweating

indigestion

irregular, fast, slow, or shallow breathing

large, flat, blue or purplish patches in the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of consciousness

low body temperature

muscle cramping, weakness, or tremors

muscle pain or stiffness

nausea or vomiting

nosebleeds

numbness or tingling in the hands, feet, or lips

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

pinpoint red or purple spots on the skin

prolonged bleeding from cuts

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red or black, tarry stools or dark urine

restlessness

shivering

shortness of breath

skin rash

sleepiness

sunken eyes

sweating

swelling of face, ankles, hands, feet, or lower legs

thirst

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

vomiting of material that looks like coffee grounds, severe and continuing

weak or feeble pulse

weakness or heaviness of the legs

weight gain

wheezing

wrinkled skin

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Continuing ringing or buzzing or other unexplained noise in the ears

decreased awareness or responsiveness

diarrhea

drowsiness

enlarged pupils

extremely high fever or body temperature

fast, weak heartbeat

hearing loss

increase in heart rate

restlessness

severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Relaxed and calm feeling

sleepiness

Incidence not known

Belching

bloated, full feeling

blurred or loss of vision

change in color perception

cold sweats

constricted, pinpoint, or small pupils (black part of the eye)

cool, pale skin

double vision

excess air or gas in the stomach

false or unusual sense of well-being

flushed, dry skin

fruit-like breath odor

halos around lights

increased hunger or thirst

increased urination

lack or loss of strength

night blindness

nightmares

overbright appearance of lights

red eyes

redness of the skin

seeing, hearing, or feeling things that are not there

shakiness

sleepiness or unusual drowsiness

slurred speech

trouble sleeping

tunnel vision

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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