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FDA Update

Oxycodone / Acetaminophen

Oxycodone/acetaminophen (Roxicet, Endocet, Percocet) is a moderately priced drug used to treat moderate to severe pain.This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic oxycodone/acetaminophen is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of oxycodone / acetaminophen is around $20.08, 81% off the average retail price of $111.11. Compare opioid / acetaminophen combinations.

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10 Medications That are Dangerous to Stop Abruptly

Dr. Sharon Orrange - December 21, 2016

“Can I just stop my medication?” This question, frequently asked of primary care doctors, has a complicated answer. For starters, if you are taking a medication that is controlling an ongoing medical problem like high blood pressure, diabetes, or high cholesterol you should never stop it on your own—or your problem will return. Many patients do come clean though, and report that they just plain stopped their meds. See More

Opioid Overdoses: How Do We Balance Help and Harm?

Dr. Sharon Orrange - February 04, 2016

Opioid pain medication is an emotional topic for everyone. Patients who struggle with chronic noncancer pain and need opioid medications feel they are portrayed as addicts when they ask for refills. Each week I see many patients using opioids for the appropriate reason, who have tried and failed with other medications and yet feel stigmatized by the use of medicine they need.

The flipside, however, is that more and more of us are dying from prescription pain medication overdoses, in addition to heroin overdoses when addicts move from Oxycontin to heroin. See More

Does Medical Marijuana Prevent Prescription Drug Abuse and Overdose?

Dr. Sharon Orrange - February 12, 2015

Twenty-three states and the District of Columbia have now passed medical marijuana laws, and four more have pending legislation to legalize medical marijuana. Meanwhile, the use of prescription opioid medications (hydrocodone, oxycodone) has increased as the number of Americans with chronic non-cancer pain has increased. With that, we have seen in the United States the disturbing rise in prescription opioid abuse and overdose deaths. See More

Is Your Medication Making You Tired?

Dr. Sharon Orrange - June 10, 2014

One in ten visits to a primary care doctor is for fatigue. While certainly not the only cause, your medications can be the culprit for making you sleepy. Here are the players you need to know about.

Beta blockers. These are medications used for high blood pressure, migraine prevention, control of heart rate in atrial fibrillation, and they improve mortality after heart attack. Ok, now for the downside. They can make you sleepy. See More

Is Nucynta Better Than Other Pain Meds?

Dr. Sharon Orrange - April 23, 2014

One of the bright new changes in pain medications over the last few years were two medications: Ultram (tramadol) and now Nucynta (tapentadol). These are different from Vicodin (hydrocodone/acetaminophen), Percocet (oxycodone/acetaminophen), and Tylenol #3 (codeine/acetaminophen) in many ways and are considered much “gentler.” So, is Nucynta better? Lets look.

Ten points about Nucynta and Ultram you need to know:

  1. See More

Which Medicine Is Best for Pain: Percocet, Vicodin, or Tylenol #3?

Dr. Sharon Orrange - April 16, 2014

You’ve had surgery, you have a toothache, or you can’t move without severe back pain and Tylenol (acetaminophen) and ibuprofen aren’t helping. What’s next?

Conventionally, patients who have moderate to severe pain have been offered one of the opioid-nonopioid combination drugs, such as acetaminophen plus hydrocodone or oxycodone.

Are they the same? What’s better? What is the prescription I have? It seems complicated but it’s not—let’s shed light on the common players:

Acetaminophen + Codeine:

You may have been prescribed Tylenol #3 or Tylenol #4 in the past. See More

Prescription Acetaminophen Dose Changes: What You Need to Know

Roni Shye - January 17, 2014

General Overview

What has been discontinued?

All prescription drug products with more than 325 mg of acetaminophen (also known as APAP or paracetamol, and the active ingredient in Tylenol). The FDA has asked that manufacturers limit the amount of acetaminophen in these products to 325 mg to prevent liver injury from overdose.

Some examples of these drugs include Vicodin (hydrocodone/acetaminophen), Percocet (oxycodone/acetaminophen), Fioricet (butalbital/acetaminophen/caffeine), and Fioricet with codeine (butalbital/acetaminophen/caffeine/codeine). See More

Prescription Drug Abuse: A Pharmacist’s View

Roni Shye - November 01, 2013

Controlled substances and prescription drug abuse have been increasingly under the spotlight. This has been fueled, in particular, by overuse of drug such as opioids. Opioids are used as painkillers and include hydrocodone, oxycodone, hydromorphone, and morphine. Hydrocodone and oxycodone are among the top most abused prescription drugs.

The numbers:

Overdose is the second leading causing of accidental death in the United States, with an estimated 16,600 deaths from overdose in 2010. See More

Acetaminophen: Curbing Overdose and Liver Toxicity

Roni Shye - October 11, 2013

Acetaminophen (Tylenol) toxicity has become more of an issue, especially due to the rise of combination products. These include prescription pain medications (such as hydrocodone/acetaminophen, oxycodone/acetaminophen, butalbital/acetaminophen, acetaminophen/codeine and tramadol/acetaminophen) in which acetaminophen is used as a second pain reliever. It is also widely available over the counter, and many over-the-counter combinations that advertise pain or fever relief contain acetaminophen as well. See More

FDA Warning: Rare But Serious Acetaminophen (Tylenol) Reaction

Elizabeth Davis - August 02, 2013

If you notice a rash, blister, or other skin reaction while taking any drug containing acetaminophen, you should stop taking the medication immediately and contact your doctor or other health provider. The symptoms can be signs of three rare but very serious skin disorders, caused by a reaction to the acetaminophen.

Acetaminophen is the active ingredient in Tylenol and many over-the-counter combination cough and cold products. See More

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