Crizotinib Side Effects
What should I watch for?
Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Tell your doctor about any unusual symptoms.
Tell your doctor or health care professional right away if you have any change in your eyesight. Do not drive or use machinery if you have a change in your eyesight.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
Women should not become pregnant while taking this medicine and for at least 45 days after the last dose. Men should use condoms during treatment and for at least 90 days after the last dose. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine and for 45 days after the last dose.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Black, tarry stools
bloating or swelling of the face, arms, hands, lower legs, or feet
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
cough or hoarseness
difficult or labored breathing
fever or chills
increased sensitivity to pain or touch
lightheadedness, dizziness, or fainting
loss of voice
lower back or side pain
painful or difficult urination
rapid weight gain
runny or stuffy nose
slow or irregular heartbeat
tightness in the chest
ulcers, sores, or white spots in the mouth
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
weakness in the arms, hands, legs, or feet
blood in the urine or stools
pinpoint red spots on the skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Abdominal or stomach discomfort, pain, or tenderness
acid or sour stomach
change in taste
decrease or change in vision
difficulty having a bowel movement (stool)
difficulty with moving
difficulty with swallowing
increased sensitivity of the eyes to sunlight
muscle pain or stiffness
pain in the joints
pain or burning in the throat
pain or discomfort in the chest, upper stomach, or throat
problems with balance
redness, swelling, or soreness of the tongue
scaling, redness, burning, pain, chapping, swelling, or other signs of inflammation of the lips
seeing flashes or sparks of light
swelling or inflammation of the mouth
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.