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GLP-1 Agonists

GLP-1 agonists are used to treat diabetes type 2 and obesity. They work by increasing insulin release and reducing appetite.

Why are glp 1 agonists prescribed?

  1. Diabetes Type 2 (74%)
  2. Weight Loss (26%)

Key takeaways

GLP-1 agonists are used to treat Type 2 diabetes, help with chronic weight management, and reduce the risk of major cardiovascular events in certain people. They work by mimicking the action of the glucagon-like peptide-1 (GLP-1) hormone, which helps to increase natural insulin release, decrease the amount of glucose (sugar) the liver makes, and slow down gastric emptying. This leads to better blood glucose balance and weight loss. GLP-1 agonists come in different forms, including oral tablets and injections. Examples include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity). You can discuss with your healthcare team which option might be right for you.

Prices for popular GLP-1 Agonists medications
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Ozempic

as low as$25
Ozempic (semaglutide) is used to improve blood sugar control in adults with type 2 diabetes. Ozempic is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices could help offset the cost. Ozempic is a GLP-1 Agonist which works by increasing insulin release and reducing appetite. The most common form of Ozempic is a 2mg prefilled pen. Ozempic is also available as a 3mg prefilled pen. There are currently no generic alternatives for Ozempic.
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Wegovy

as low as$1,298
Wegovy (semaglutide) is used to help people lose weight and maintain weight loss. Wegovy is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Wegovy is a GLP-1 Agnonist, which works by increasing insulin release and reducing appetite. It is used with a reduced calorie diet and exercise. Wegovy is available as cartons of four prefilled pens. There is currently no generic alternative to Wegovy.
Victoza (liraglutide) is used to treat diabetes type 1 and diabetes type 2. Victoza is a GLP-1 agonist, which works by helping the pancreas produce more insulin. The most common form of Victoza is a carton of three 18mg/3ml pens. It is also available as a carton of two 18mg/3ml pens. There are currently no generic alternatives for Victoza. It is covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost.
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Rybelsus

as low as$10
Rybelsus (semaglutide) is used to improve blood sugar control in adults with type 2 diabetes. Rybelsus is a GLP-1 Agonist, which works by increasing insulin release and reducing appetite. The most common form of Rybelsus is a 7mg tablet. It's also available in 3mg and 14mg tablets. There are currently no generic alternatives for Rybelsus. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Adlyxin

as low as$657
LIXISENATIDE treats type 2 diabetes. It works by increasing insulin levels in your body, which decreases your blood sugar (glucose). It also reduces the amount of sugar released into your blood and slows down your digestion. Changes to diet and exercise are often combined with this medication.
Exenatide (Byetta) is an expensive drug used to improve blood sugar control in adults with type 2 diabetes. This medicine may be used with other oral diabetes medicines. This drug is less popular than comparable drugs. There are currently no generic alternatives for Byetta. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Bydureon Bcise (Exenatide) is used to improve blood sugar control in adults with type 2 diabetes. This medicine may be used with other oral diabetes medicines. Bydureon Bcise is less popular than other diabetes type 2 medications. There are currently no generic alternatives to Bydureon Bcise.

GoodRx has partnered with InsideRx and AstraZeneca to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Bydureon Bcise is covered by some Medicare and insurance plans.
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Trulicity

as low as$864
Trulicity (dulaglutide) is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Trulicity is a GLP-1 Agonist which works by increasing insulin release and reducing appetite. The most common form of Trulicity is a carton of 4 pens. There are currently no generic alternatives for Trulicity. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Saxenda

as low as$1,298
Saxenda (liraglutide) promotoes weight loss. It may also be used to maintain weight loss. Saxenda is a is a GLP-1 Agonist which works by increasing insulin release and reducing appetite. Saxenda is only avalible as a carton of five 3ml pens. There are currently no generic alternatives for Saxenda. It is covered by some Medicare and insurance plans, but some pharmacy coupons, manufacturer programs, or cash prices may be lower.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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