Cetrorelix (Cetrotide) is an injectable fertility medication that's used during in vitro fertilization (IVF). It belongs to a drug class called GnRH antagonists. It helps prevent your body from releasing eggs too early before egg retrieval in the IVF process. You typically inject a dose of the medication under the skin once a day on certain days of the IVF cycle. Potential side effects include ovarian hyperstimulation syndrome, nausea, and headache.
Cetrorelix (Cetrotide) is a gonadotropin releasing hormone (GnRH) antagonist. It works by blocking GnRH, a hormone that normally helps prepare your body for ovulation (the release of an egg from your ovary).
By blocking GnRH, cetrorelix (Cetrotide) temporarily delays ovulation. This prevents the ovary from releasing eggs too soon before egg retrieval. It can help egg retrieval be more successful.
| Common Brands | Cetrotide |
|---|---|
| Drug Class | GnRH antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
How to prepare and how to inject cetrorelix (Cetrotide):
Cetrorelix (Cetrotide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Severe allergic reactions to cetrorelix (Cetrotide) can happen. This can include a life-threatening reaction called anaphylaxis. The risk might be higher if you're allergic to mannitol, an ingredient in this medication.
Call 911 right away if you notice any signs of a serious allergic reaction after your cetrorelix (Cetrotide) injection. Look out for hives, rash, swelling of your lips or tongue, coughing, and trouble breathing.
You shouldn't use cetrorelix (Cetrotide) if you're pregnant. Based on animal studies, this medication might harm an unborn baby. Your prescriber might order a pregnancy blood test before you start fertility treatment to make sure you're not pregnant.
Tell your fertility specialist right away if you get pregnant while using cetrorelix (Cetrotide).
Kit| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.25mg | 5 kits | $288.34 | $57.67 |
The typical dose is 0.25 mg injected under the skin once a day.
Your fertility specialist will tell you when to start and stop cetrorelix (Cetrotide). Usually, you start the injections on either stimulation day 5 (in the morning or evening) or day 6 (in the morning). You'll keep doing daily injections of cetrorelix (Cetrotide) until you need to inject hCG (your trigger shot).
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cetrorelix (Cetrotide) will not be safe for you to take.
Prescription savings
Stop paying too much for your prescriptions. Compare prices, get pharmacy coupons, and save up to 80%.
Find expert answers to your health questions so you can make the best decisions for yourself and your family.Health conditions
Medications & treatment
Access & affordability
Our monthly healthcare membership can help you save thousands on your prescription costs.Resources
The number of days you use Cetrotide before your trigger shot can be different for everyone. This is because it depends on how fast your eggs grow and mature inside your ovaries. It also depends on the specific protocol your fertility specialist is following. In general, most people use Cetrotide for less than a week. Your fertility specialist might be able to give you an estimate based on your ultrasound scans.
No, Cetrotide and ganirelix aren't the same. But they work in the same way and are under-the-skin injections that are used during the IVF process. They both help prevent eggs from releasing from the ovary too early before retrieval. Your fertility specialist might choose one over the other based on many things. This includes your particular situation, preferences, treatment plan, medication cost, or medication availability. They can help you compare and decide which option is best for you.
Yes. Make sure to keep Cetrotide in the refrigerator until you're ready to use it. You can use the medication up until its expiration date when it's stored in the fridge.
If you need to adjust the time you inject Cetrotide, talk to your fertility specialist. There isn't enough information to know how well it works when taken at different times every day.
During studies, people didn't usually say they felt tired while using Cetrotide. If you feel more tired than usual and you're not sure why, reach out to your healthcare professional. They can help you figure out what might be going on.
You should inject Cetrotide under the skin of your lower stomach. Make sure it's at least 1 inch away from your belly button. Since you inject the medication under the skin, be sure to pinch your skin a bit and inject into the fold of skin. Ask your fertility team or pharmacist about how to inject Cetrotide.
Cetrotide starts working within 2 hours after the injection to stop the release of a hormone called luteinizing hormone (LH). Together with GnRH, LH helps your body prepare for ovulation. By blocking GnRH, Cetrotide stops LH from releasing in the body. This helps delay ovulation. You won't feel it working, so it's important to use the medication every day as your fertility specialist tells you so it keeps working. They'll let you know when to stop. This is usually based on your ultrasound results, which check if you're ready for egg retrieval.
