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Carfilzomib

Kyprolis

CARFILZOMIB targets a specific protein within cancer cells and stops the cancer cells from growing. It is used to treat multiple myeloma. Compare proteasome inhibitors.
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What is Carfilzomib?

Commonly Used Brand Name(s)Kyprolis

Therapeutic ClassificationsAntineoplastic Agent

Pharmacologic ClassificationsProteasome Inhibitor

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OverviewTOP

Carfilzomib injection is used alone or together with other medicines (eg, dexamethasone, lenalidomide) to treat multiple myeloma (a type of bone marrow cancer) in patients who have received other treatments that did not work well. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Carfilzomib is an antineoplastic agent (cancer medicine).

This medicine is to be given only by or under the supervision of your doctor.

Proper UseTOP

A nurse or other trained health professional will give you this medicine in a hospital or cancer clinic. This medicine is given through a needle placed in a vein.

This medicine needs to be given on a fixed schedule. Be sure to keep all appointments.

Drink extra fluids so you will pass more urine while you are receiving this medicine. This may help prevent kidney problems and other unwanted effects.

You might also receive medicines (eg, dexamethasone) to help prevent unwanted reactions to the injection.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies have not been performed on the relationship of age to the effects of carfilzomib injection in the pediatric population. Safety and efficacy have not been established.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of carfilzomib injection in the elderly.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Yellow Fever Vaccine

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

PrecautionsTOP

It is very important that your doctor check you at regular visits while you are receiving this medicine to make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control during treatment and for at least 30 days after the last dose to keep from getting pregnant. Male patients must also use an effective form of birth control to prevent pregnancy in a sexual partner during treatment and for at least 90 days after the last dose. If you think a pregnancy has occurred with this medicine, tell your doctor right away.

This medicine may cause serious heart problems. Tell your doctor right away if you have chest pain or discomfort, shortness of breath, irregular heartbeats, or swelling of the feet, ankles, or legs while you are receiving this medicine.

Kidney problems may occur while you are receiving this medicine. Tell your doctor if you have the following symptoms: agitation, confusion, decreased urine output, depression, headache, rapid weight gain, swelling the face, ankles, or hands, or unusual tiredness or weakness.

This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor right away if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or feel tired.

Blood clots may occur while you are receiving this medicine. Tell your doctor right away if you have chest pain, dizziness or lightheadedness, fainting, fast heartbeat, pain, redness, or swelling in the arm or legs, sudden shortness of breath, trouble breathing.

This medicine may cause you to be more dizzy, lightheaded, or tired than normal. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Getting up slowly from a sitting or lying position may help prevent lightheadedness or dizziness. Tell your doctor if you feel dizzy or lightheaded.

This medicine may cause a serious type of allergic reaction called an infusion reaction. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a cough, difficulty with swallowing, dizziness, a fast heartbeat, chest tightness, trouble breathing, swelling in your face or hands, a fever, chills, itching or hives, or lightheadedness or faintness while you are receiving this medicine.

This medicine can lower the number of platelets in your blood, which are needed for blood clotting. Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, or pinpoint red spots on your skin.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Tell your doctor right away if you have seizures, headache, confusion, vision problems, unusual drowsiness, tiredness, or weakness. These could be symptoms of a serious nervous system problem called posterior reversible encephalopathy syndrome (PRES).

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