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Cabozantinib
Specialty Drug

Cometriq

CABOZANTINIB is medicine that targets proteins in cancer cells and stops the cancer cell from growing. It is used to treat thyroid cancer and renal cell cancer. Compare VEGF antibodies.
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Cabozantinib Side Effects

What should I watch for?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

If you are going to have surgery or any other procedures, tell your doctor you are taking this medicine.

Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 4 months after the last dose.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision

burning, numbness, tingling, or painful sensations

dehydration

difficulty with breathing or swallowing

dizziness

headache

nervousness

pain in the chest, groin, or legs, especially the calves

pounding in the ears

redness, swelling, or pain of the skin

scaling of the skin on the hands and feet

severe, sudden headache

skin ulcers

slow or fast heartbeat

slurred speech

sudden loss of coordination

sudden, severe weakness or numbness in the arm or leg

sudden, unexplained shortness of breath

tingling of the hands and feet

unsteadiness or awkwardness

vision changes

weakness in the arms, hands, legs, or feet

Less common

Bleeding gums

bloody, black, or tarry stools

coughing up blood

heartburn

heavy jaw feeling

increased menstrual flow or vaginal bleeding

indigestion

loosening of a tooth

nausea

nosebleeds

pain, swelling, or numbness in the mouth or jaw

paralysis

prolonged bleeding from cuts

red or dark brown urine

severe abdominal or stomach pain, cramping, or burning

trouble breathing

vomiting of material that looks like coffee grounds, severe and continuing

Rare

Confusion

disturbed color perception

double vision

halos around lights

night blindness

overbright appearance of lights

seizures

tunnel vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

bleeding after defecation

change in taste

changes in hair color

decreased appetite

decreased weight

diarrhea

difficulty having a bowel movement (stool)

difficulty with moving

dry skin

fear

hair loss or thinning of the hair

hoarseness

lack or loss of strength

loss of taste

muscle pain or stiffness

muscle spasm

pain in the joints

rash

sore throat

stomach discomfort, upset, or pain

swelling or inflammation of the mouth

uncomfortable swelling around the anus

voice changes

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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