Nexium (Esomeprazole Magnesium) vs Esomeprazole Strontium: What’s the Difference?

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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With almost identical active ingredient names, these medications can be easy to confuse—but esomeprazole strontium is not a generic equivalent to Nexium. Although both treat GERD (heartburn), they are available in different strengths and have different advantages.

What is GERD?

GERD or gastroesophageal reflux disease is more commonly known as heartburn. Heartburn is a form of indigestion in which your stomach acid comes back up into the esophagus.

What are the dosage forms for these medications?
Nexium (esomeprazole magnesium) is available as a capsule and an oral suspension packet. Esomeprazole strontium is available as a capsule only.

What are the strengths for these medications?
Nexium (esomeprazole magnesium) is available in 20 mg and 40 mg strengths, which esomeprazole strontium is available in a 49.3 mg strength only.

What type of medication are esomeprazole magnesium and strontium?

Both Nexium (esomeprazole magnesium) and esomperazole strontium are considered PPI(s) or Pronton Pump Inhibitor(s).

PPIs work by shutting off the “pumps” in the body responsible for releasing acid in the stomach. They decrease the amount of acid in the stomach and help control the symptoms of acid reflux or GERD.

What are the advantages of using Nexium (esomeprazole magnesium)?

What are the advantages of using esomeprazole strontium?

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