Glynase vs Diabeta: What’s the Difference?

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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First, let’s talk about what makes Glynase and Diabeta similar. Both of these medications are used in type 2 diabetes to improve glycemic control and lower blood sugar levels, both are 2nd generation drugs in the sulfonylurea class and work by telling the pancreas to release more insulin, and both have a form of glyburide as the active ingredient.
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So, how does Glynase differ from Diabeta?
Glynase is micronized glyburide which has a different duration of action, absorption, and dosage than its nonmicronized counterpart, Diabeta or Micronase (regular glyburide). Micronized glyburide contains smaller particles that allow the medication to be absorbed better by the body—therefore, lower doses can be used.

What are the available strengths and MAX dose of Glynase?
Glynase (micronized glyburide) comes in 1.5 mg, 3 mg, and 6 mg tablets. The max dose is 12 mg per day.

What are the available strengths and MAX dose of Diabeta and glyburide?
Diabeta and generic glyburide come in 1.25 mg, 2.5 mg, and 5 mg tablets. The max dose 20 mg per day.

How are these medications taken?

Both Glynase and Diabeta are usually taken once or twice daily before meals.

What if you have a SULFA allergy?

A reaction is possible with any of the sulfonylureas, however, remember, glyburide is a 2nd generation sulfonylurea. Reactions occur more frequently with the 1st generation sulfonylurea, chlorpropamide (Diabinese).

Can these medications be substituted for one another?

NO. Although glyburide is the active ingredient in both Diabeta and Glynase, the formulations DO differ.

You can find prices and more information about Glynase here, and you can find prices and more information about Diabeta here. Micronase (glyburide) is also available.

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