FDA Approves Trulance for Constipation

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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If I had to describe constipation in one word, I would say the majority of people would agree that its uncomfortable. Not only can constipation be uncomfortable, but it can also be frustrating and painful for people of all ages.

Constipation can be caused by the medications you take, the diseases you’ve been diagnosed with, how old you are, or even how much water you drink. Although occasional constipation can be very common, some people may experience a more chronic type of constipation that can interfere with their daily lives.

For these chronic issues, the FDA approved Trulance on January 19th, a once-daily prescription medication for adults with chronic idiopathic constipation (CIC).

What is Trulance indicated for?

Trulance is indicated for the treatment of chronic idiopathic constipation (CIC) in adults 18 years of age and older.

What is chronic idiopathic constipation?

“Idiopathic” actually means that the cause of constipation is unknown. Therefore, those with chronic idiopathic constipation have infrequent bowel movements, difficulty passing stools, or both, without an identifiable cause.

Bowel movements in those with constipation is defined as as a decreased stool frequency, or less than three bowel movements per week.

What are the common causes of constipation?

The following are common causes of constipation

What dosage form(s) and strength(s) will Trulance be available in?

Trulance will be available in a 3 mg tablet.

How should I take Trulance?

The recommended dose of Trulance is one 3 mg tablet once daily, with or without food.

Trulance tablets should be swallowed whole. However, if a patient has difficulty swallowing, or has a feeding tube, tablets may be crushed and mixed in food or water.

What are the common side effects associated with Trulance?

The most common side effect associated with Trulance is diarrhea. If you experience severe diarrhea, you should stop taking Trulance and contact your health care provider.

Trulance also contains a Boxed Warning regarding the increased risk of serious dehydration in pediatric patients.

When will Trulance be available?

Trulance is expected to be available later this quarter according to the manufacturer Synergy Pharmaceuticals. You can read their press release here.

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