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Morphine Once-Daily

MORPHINE is a pain reliever. It is used to treat moderate to severe pain that lasts for more than a few days. It is used by people who have been taking an opioid or narcotic pain medicine. Compare opioids.
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Avinza Side Effects

What should I watch for?

Tell your doctor or health care professional if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to the medicine. Tolerance means that you will need a higher dose of the medicine for pain relief. Tolerance is normal and is expected if you take for a long time.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If you have pain, you have a medical reason to take pain medicine. Your doctor will tell you how much medicine to take. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

There are different types of narcotic medicines (opiates). If you take more than one type at the same time or if you are taking another medicine that also causes drowsiness, you may have more side effects. Give your health care provider a list of all medicines you use. Your doctor will tell you how much medicine to take. Do not take more medicine than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Blurred vision

confusion

decrease in the frequency of urination

decrease in urine volume

difficulty in passing urine (dribbling)

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

fast, pounding, or irregular heartbeat or pulse

painful urination

pale skin

shortness of breath

sweating

unusual tiredness or weakness

Less common

Abdominal or stomach cramps or pain

bloating

constipation

convulsions

diarrhea

difficult or labored breathing

dry mouth

increased thirst

irregular, fast, slow, or shallow breathing

loss of appetite

mood changes

muscle pain or cramps

pale or blue lips, fingernails, or skin

restlessness

shakiness

sleepiness

slow to respond

slurred speech

tightness in the chest

unconsciousness

vomiting

wheezing

Incidence not known

Bluish lips or skin

disorientation

hallucinations

lethargy

low blood pressure or pulse

severe drowsiness

slowing of the heartbeat

unresponsiveness

very slow breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bloated or full feeling

excess air or gas in the stomach or intestines

fever

headache

nausea

passing gas

skin itching

sleeplessness

trouble sleeping

troubled breathing with exertion

unable to sleep

unusual bleeding or bruising

Less common

Back pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain or discomfort

fear or nervousness

feeling unusually cold

lower abdominal or stomach pain or pressure

pounding in the ears

pressure in the stomach

shivering

slow or irregular heartbeat

swelling of the abdominal or stomach area

Incidence not known

Not alert

trouble with coordination

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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