Medications are a common offender when it comes to lower extremity edema, either as the cause or as a factor that can make it worse. Swelling in the lower legs from fluid in the tissues—lower extremity edema—is a familiar complaint among patients. Imprints from your socks, puffy legs, and feet so you can’t put your shoes on, or swelling so that you can make an indent with your thumb (pitting edema) may lead you to wonder what’s going on. See More
Avandia Latest News
Get the latest updates on this drug from the GoodRx medical team
In a non-diabetic person, insulin is released from the pancreas with each meal and it helps the body either use or store the glucose it gets from the food. Patients who have type I diabetes don’t produce insulin, and must inject themselves with insulin to mimic the body’s natural process.
Type II diabetics, on the other hand, still produce insulin but their bodies do not use it properly. Type II diabetics can be treated with oral medications, insulin, other injectables, or a combination of different medications. See More
Since 2010, use of diabetes med Avandia has been restricted to patients who weren’t able to control their diabetes using other medication options. Studies showed an increased risk of heart problems, and the manufacturer, GlaxoSmithKline, plead guilty and was fined for witholding safety information about Avandia.
This story should get under your skin. GlaxoSmithKline (GSK), the drug company that makes Wellbutrin (bupropion), has agreed to pay $3 billion to the federal government. GSK plead guilty to charges of illegally promoting two antidepressants and withholding key safety information about the diabetes drug Avandia.
As part of the settlement, the drug company admitted promoting the drugs Paxil (paroxetine) and Wellbutrin for off-label uses and failing to report safety data about the diabetes medication Avandia. See More