Acetaminophen (Tylenol) is combined with other active ingredients like diphenhydramine (Benadryl), and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain and fever.

Why are
Acetaminophen Combinations
prescribed?

How is this chart calculated?

How we make this chart

This chart is created by aggregating the total number of claims for the drugs in this class divided by the # of drugs with a specific indication. It is meant to be representative but may not accurately reflect the actual # of prescriptions written to treat a specific condition.

Prices for Popular Acetaminophen Combinations

Popularity Brand Name (Generic Name) GoodRx Fair Price Price Trend
Excedrin Migraine
N/A N/A See Prices
ACETAMINOPHEN; ASPIRIN; CAFFEINE is a pain reliever. It is used to treat mild aches and pains. This medicine may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis, and toothache.
Nyquil
N/A N/A See Prices
ACETAMINOPHEN; DEXTROMETHORPHAN; DOXYLAMINE is a combination of a pain reliever, a cough suppressant, and an antihistamine. It is used to treat the aches and pains, cough, fever, headache, runny nose, and sneezing of a cold. This medicine will not treat an infection.
Excedrin Extra Strength
N/A N/A See Prices
ACETAMINOPHEN; ASPIRIN; CAFFEINE is a pain reliever. It is used to treat mild aches and pains. This medicine may help with arthritis, colds, headache (including migraine), muscle aches, menstrual cramps, sinusitis, and toothache.
Excedrin Back And Body
N/A N/A See Prices
Mapap Cold
N/A N/A See Prices
ACETAMINOPHEN; DEXTROMETHORPHAN; PHENYLEPHRINE is a combination of pain reliever, a cough suppressant, and a decongestant. It is used to treat the aches and pains, cough, and congestion of a cold. This medicine will not treat an infection.
Tylenol PM
(acetaminophen pm)
N/A N/A See Prices
Tylenol Cold Daytime
N/A N/A See Prices
ACETAMINOPHEN; DEXTROMETHORPHAN; PHENYLEPHRINE is a combination of pain reliever, a cough suppressant, and a decongestant. It is used to treat the aches and pains, cough, and congestion of a cold. This medicine will not treat an infection.
Tylenol Cold Nighttime
N/A N/A See Prices
Mapap PM
(acetaminophen pm)
N/A N/A See Prices
Excedrin PM
N/A N/A See Prices
ACETAMINOPHEN; DIPHENHYDRAMINE is a pain reliever antihistamine combination. It is used to treat allergy symptoms like sore throat, runny nose, sneezing, and itching of the eyes, nose, and throat. Or, this medicine is used to treat pain and help you fall to sleep.
Tylenol Cold Severe
N/A N/A See Prices
ACETAMINOPHEN; DEXTROMETHORPHAN; GUAIFENESIN; PHENYLEPHRINE is a combination of a pain reliever, a cough suppressant, an expectorant, and a decongestant. It is used to treat the aches and pains, fever, cough, and congestion of a cold. This medicine will not treat an infection.

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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