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COLLAGENASE is used to treat Dupuytren's contracture. This medicine may help straighten a bent finger by breaking up hard tissue. It is also used for Peyronie's disease by breaking up the hard tissue plaque that causes the curvature in the penis. Compare collagen-specific enzymes.
Xiaflex Coupon - Xiaflex 0.9mg vial

Xiaflex Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine.

If being treated for Dupuytren's contracture, return to your healthcare provider the day after your hand is injected. In the meantime, do not flex or extend the fingers of your hand that was injected. Do not touch your finger that was injected, and elevate your hand until bedtime. Do not perform activity with the injected hand until you are told that it is OK. Follow any instructions about wearing a splint or performing finger exercises. Also, call your healthcare provider if you get increasing redness or swelling in the hand, if you have numbness or tingling in the treated finger, or if you have trouble bending the finger after the swelling goes down.

If being treated for Peyronie's disease, you will need to return to your healthcare provider for a manual procedure that will stretch and help straighten your penis. Also, your healthcare provider will show you how to gently stretch your penis at home. Do not resume sexual activity until you are told that it is okay. Follow instructions on when to return for follow-up visits. Immediately call your doctor if you have trouble stretching or straightening your penis, or if you have pain or other concerns.

Immediately call your healthcare provider if you get a fever or chills.


Interactions with Medications

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—Dupuytren's contracture

Bruising or bleeding at the injection site

swelling of the hands

tearing of the skin

More common—Peyronie's disease

Itching, pain, redness, swelling, or bruise of the penis

popping sound or sensation in an erect penis

Less common—Peyronie's disease

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

painful sexual intercourse

Incidence not known—Dupuytren's contracture

Bone pain

lower back or side pain

painful, swollen joints

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—Dupuytren's contracture

Blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, lumps, numbness, rash, scarring, stinging, tingling, or ulceration at the injection site


flushing, redness of the skin or unusually warm skin at the injection site

itching, pain, swelling, or tenderness at the injection site

swollen, painful, or tender lymph glands in the neck or armpit

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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